程道军

二级教授，博士生导师

国家高层次人才特殊支持计划科技创新领军人才

科技部中青年科技创新领军人才

重庆市“巴渝学者”特聘教授

重庆市学术技术带头人

学习工作经历

2023-至今  西南大学前沿交叉学科研究院生物学研究中心    副主任

2018-2023  家蚕基因组生物学国家重点实验室                    副主任

2015-至今  西南大学                                                          研究员

2011-2012 哈佛大学                                                          访问学者

2008-2015 西南大学                                                          副研究员

2003-2008 西南大学/西南农业大学                                    助理研究员

1994-2003  西南农业大学                                                  实验师

1990-1994  四川省蚕丝学校                                               中专

2000-2003 西南农业大学                                                    硕士

2005-2008 西南大学                                                           博士

荣誉获奖

2021  国家高层次人才特殊支持计划科技创新领军人才

2021  科技部中青年科技创新领军人才

2021 重庆市自然科学奖二等奖

2021  川渝科技学术大会优秀论文一等奖

2019  重庆市学术技术带头人

2017  重庆市“巴渝学者”特聘教授

研究领域

     以家蚕和果蝇为模式，聚焦表观遗传、蛋白翻译后修饰、生物组学等前沿领域，重点开展以下四个方面的研究：1）内分泌激素的生物合成与信号转导；2）生长发育与营养代谢稳态的表观遗传调控；3）丝腺分化发育与丝蛋白合成调控；4）基于基因编辑等生物技术的家蚕新种质创制。

学术贡献

     致力于家蚕遗传与发育生物学研究。近年来结合家蚕和果蝇中的研究，取得系列突破性进展：1）解析昆虫保幼激素与蜕皮激素两大内分泌激素的酶促合成通路，阐明两者拮抗互作的新机制，并揭示蛋白质磷酸化修饰途径在蜕皮激素信号转导中的重要作用；2）阐明组蛋白甲基化、乙酰化和泛素化等蛋白翻译后修饰对昆虫生长发育、脂代谢等生物学过程的表观遗传调控；鉴定发现唾液腺特异的内分泌因子，系统解析其对脑中胰岛素分泌、个体生长及器官大小的调控作用；3）揭示去泛素化修饰介导的蛋白稳态维持途径在家蚕丝腺核内复制细胞周期、丝腺发育及丝蛋白合成中的调控功能；4）建立基于CRISPR/Cas13系统的家蚕RNA编辑体系，应用基因编辑和转基因等策略创制获得高产丝量的家蚕优良新种质。

     主持国家自然科学基金、科技部科技创新领军人才计划、重庆市技术创新与应用发展专项重点项目、重庆市自然科学基金等多项国家级和省部级项目。作为通讯作者在PNAS（2024，2021，2018）、Science Advances、Cell Reports、Nucleic Acids Research、PLoS Genetics、Journal of Biological Chemistry、Zoological Research、Insect Biochemistry and Molecular Biology、Insect Science等国际主流期刊发表系列成果。作为主要合作作者在Science、Cell Metabolism、Genome Biology等国际知名期刊发表研究论文。参编《蚕的基因组》《中国养蚕学》等学术专著。获授权发明专利3项。

     指导毕业的博士生和硕士生5人次获评重庆市优秀博士/硕士学位论文，1人入选首批中国科协青年人才托举工程博士生专项计划，多人次获评研究生国家奖学金、全国大学生蚕桑生物技术大赛一等奖、侯光炯奖学金一等奖、校级优秀研究生标兵、三好学生、国际国内学术会议优秀报告奖等奖励。

学术兼职

2025-至今  Zoological Research期刊编委

2023-至今  中国昆虫学会昆虫发育与遗传专业委员会委员

2023-至今  重庆市生物化学与分子生物学学会农业专委会副主任

2023-至今  重庆市昆虫学会常务理事

2020-至今  Frontiers in Physiology编委（Topic Editor）

2020-至今  Frontiers in Endocrinology编委（Review Editor）

2020-至今  Frontiers in Insect Science编委（Review Editor）

2018-至今  中国昆虫学会昆虫生理生化与分子生物学专业委员会委员

2015-至今  全国生物芯片标准化技术委员会委员

2015-至今  重庆市生物化学与分子生物学学会理事

代表性论文

1.Qian W#,*, Zhang X#, Yuan D#, Wu Y, Li H, Wei L, Li Z, Dai Z, Song P, Sun Q, Zhou Z, Xia Q, Cheng D*. USP8 and Hsp70 regulate endoreplication by synergistically pro1moting Fzr deubiquitination and stabilization. Sci Adv, 2025,11(12): eadq9111

2.Yuan D, Zhang X, Yang Y, Wei L, Li H, Zhao T, Guo M, Li Z, Huang Z, Wang M, Dai Z, Li P, Xia Q, Qian W*, Cheng D*. Schlank orchestrates insect developmental transition by switching H3K27 acetylation to trimethylation in the prothoracic gland. PNAS, 2024, 121(35): e2401861121

3.Tang Y#, Zhang X#, Dai Z, Li H, Yang Y, Zhao T, Yuan D, Qian W*, Cheng D*. CRISPR-Cas13-mediated RNA editing in the silkworm Bombyx mori. Zool Res, 2024, 45(6): 1249-1260

4.Qian W#, Li H#, Zhang X, Tang Y, Yuan D, Huang Z, Cheng D*. Fzr regulates silk gland growth by promoting endoreplication and protein synthesis in the silkworm. PLoS Genet, 2023,19(1): e1010602

5.Qian W#, Guo M#, Peng J, Zhao T, Li Z, Yang Y, Li H, Zhang X, King-Jones K*, Cheng D*. Decapentaplegic retards lipolysis during metamorphosis in Bombyx mori and Drosophila melanogaster. Insect Biochem Mol Biol, 2023,155: 103928

6.Zhao T#, Wang M#, Li Z, Li H, Yuan D, Zhang X, Guo M, Qian W, Cheng D*. Wds-Mediated H3K4me3 modification regulates lipid synthesis and transport in Drosophila. Int J Mol Sci, 2023, 24(7): 6125

7.Li Z#, Qian W#, Song W, Zhao T, Yang Y, Wang W, Wei L, Zhao D, Li Y, Perrimon N*, Xia Q*, Cheng D*. A salivary gland-secreted peptide regulates insect systemic growth. Cell Rep, 2022, 38(8): 110397

8.Yang Y#, Zhao T#, Li Z, Qian W, Peng J, Wei L, Yuan D, Li Y, Xia Q*, Cheng D*. Histone H3K27 methylation-mediated repression of Hairy regulates insect developmental transition by modulating ecdysone biosynthesis. PNAS, 2021, 118(35): e2101442118

9.Qian W#, Li Z#, Song W, Zhao T, Wang W, Peng J, Wei L, Xia Q*, Cheng D*. A novel transcriptional cascade is involved in Fzr-mediated endoreplication. Nucleic Acids Res, 2020, 48(8): 4214-4229

10.Zhang T#, Song W#, Li Z#, Qian W, Wei L, Yang Y, Wang W, Zhou X, Meng M, Peng J, Xia Q*, Perrimon N*, Cheng D*. Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes. PNAS, 2018, 115(15): 3960-3965

11.Qian W, Yang Y, Li Z, Wu Y, He X, Li H, Cheng D*. Enhanced Myc expression in silkworm silk gland promotes DNA replication and silk production. Insects, 2021, 12(4): 361

12.Guo M#, Qian W#, He X, Peng J, Wang P, Wang W, Xia Q, Cheng D*. Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori. Insect Sci, 2021, 28(6):1530-1540

13.Wang P, Qian W, Wang W, Guo M, Xia Q, Cheng D*. Identification and characterization of the Anillin gene in silkworm. DNA Cell Biol, 2019, 38(6): 532-540

14.Wang W, Peng J, Li Z, Wang P, Guo M, Zhang T, Qian W, Xia Q, Cheng D*. Transcription factor E93 regulates wing development by directly promoting Dpp signaling in Drosophila. Biochem Biophys Res Commun, 2019, 513(1): 280-286

15.Qian W, Gang X, Zhang T, Wei L, Yang X, Li Z, Yang Y, Song L, Wang P, Peng J, Cheng D*, Xia Q*. Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity. J Biol Chem, 2017, 292(30): 12460-12470

16.Gang X, Qian W, Zhang T, Yang X, Xia Q, Cheng D*. Aurora B kinase is required for cell cycle progression in silkworm. Gene, 2017, 599: 60-67

17.Meng M, Cheng D*, Peng J, Qian W, Li J, Dai D, Zhang T, Xia Q*. The homeodomain transcription factors Antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm. J Biol Chem, 2015, 290(40): 24438-24452

18.Meng M, Liu C, Peng J, Qian W, Qian H, Tian L, Li J, Dai D, Xu A, Li S, Xia Q*, Cheng D*. Homeodomain protein Scr regulates the transcription of genes involved in juvenile hormone biosynthesis in the silkworm. Int J Mol Sci, 2015, 16(11): 26166-26185

19.Qian W, Kang L, Zhang T, Meng M, Wang Y, Li Z, Xia Q, Cheng D*. Ecdysone receptor (EcR) is involved in the transcription of cell cycle genes in the silkworm. Int J Mol Sci, 2015,16(2): 3335-3349

20.Cheng D, Qian W, Wang Y, Meng M, Wei L, Li Z, Kang L, Peng J, Xia Q*. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1. PLoS One, 2014, 9(10): e109111

21.Cheng D, Meng M, Peng J, Qian W, Kang L, Xia Q*. Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects. Genet Mol Biol, 2014, 37(2): 444-459

22.Cheng D, Qian W, Meng M, Wang Y, Peng J, Xia Q*. Identification and expression profiling of the BTB domain-containing protein gene family in the silkworm, Bombyx mori. Int J Genomics, 2014, 2014: 86506

23.Cheng D, Peng J, Meng M, Wei L, Kang L, Qian W, Xia Q*. Microarray analysis of the juvenile hormone response in larval integument of the silkworm, Bombyx mori. Int J Genomics, 2014, 2014: 426025

24.Cheng D, Xia Q*, Duan J, Wei L, Huang C, Li Z, Wang G, Xiang Z. Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression. Insect Biochem Mol Biol, 2008,38(12): 1130-1137

25.Cheng D, Xia Q*, Zhao P, Wang Z, Xu H, Li G, Lu C, Xiang Z. EST-based profiling and comparison of gene expression in the silkworm fat body during metamorphosis. Arch Insect Biochem Physiol, 2006, 61(1): 10-23

26.Li Z#, Cheng D#, Wei L, Zhao P, Shu X, Tang L, Xiang Z, Xia Q*. The silkworm homolog of Methoprene-tolerant (Met) gene reveals sequence conservation but function divergence. Insect Sci, 2010,17(4): 313-324

27.Song W, Cheng D, Hong S, Sappe B, Hu Y, Wei N, Zhu C, O'Connor MB, Pissios P, Perrimon N. Midgut-derived activin regulates glucagon-like action in the fat body and glycemic control. Cell Metab, 2017, 25(2): 386-399

28.Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, et al. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol, 2007, 8(8): R162

29.Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, et al. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol, 2010, 28(5): 516-520

30.Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, et al. (2009) Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science, 2009, 326(5951): 433-436

31.Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 2004, 306 (5703): 1937-1940

联系方式
E-mail：chengdj@swu.edu.cn