西南大学前沿交叉学科研究院生物学研究中心（以下简称“中心”）成立于2018年8月，是遵照国家“双一流”建设总体要求，紧跟生命科学发展前沿，结合西南大学特色优势和发展需求，而成立的具有创新能力和开拓精神的研究机构。
中心立足生命科学发展的战略性、全局性、前瞻性，着力提升解决生命科学重大问题能力，以学科发展和产业振兴为己任，以“发展科学、革新技术、振兴产业、弘扬文化”的长远目标为使命，承担我校 “双一流”学科建设、生物学学科建设、中国西部（重庆）创新中心等重要任务 ，争做国际学术前沿领跑者和相关产业重要技术革新的开拓者。
中心是农业农村部长江上游种质创制重点实验室和国家重点研发计划项目的首席科学家单位，拥有重庆市蚕桑学重点实验室、重庆市蚕丝纤维新材料工程技术研究中心、蚕桑功能基因组与生物技术重庆市工程实验室等研究平台。中心现有师资队伍固定人员44人，其中教授15人，副教授17人，中级职称2人，博士后6人，行政管理4人。包括国家重要人才计划“领军人才”2人，国家重要人才计划特聘教授1人、“外国专家”1人、“青年专家”4人、获重庆市英才计划优秀科学家、两江学者、百人计划、巴渝学者、青年拔尖人才等省部级人才10人。入选教育部创新团队、农业部杰出科研人才创新团队、重庆市自然基金创新群体、重庆市优秀研究生导师团队等。研究场所面积超过3000平方米，拥有共聚焦显微镜、流式细胞仪、液质连用质谱仪等大型科研仪器设备23台，总值6千万元以上。
中心始终秉承锐意进取，开拓创新的科学研究精神，先后完成家蚕基因组框架图、精细图、变异图、基因表达图谱、蛋白质组图谱、代谢组图谱、家蚕重要经济性状分子功能解析、家蚕转基因素材创制、家蚕基因编辑技术与种质创新等重要科研任务、建立了丝蛋白表达调控、丝蛋白结构域性能、新型丝纤维材料研发、昆虫激素调控与营养信号、家蚕免疫机制与抗性品种培育、基因操作与遗传素材改良、家蚕性别决定的分子机制、比较基因组学研究等研究方向，构建了生物信息学、家蚕基因组、蛋白质组、代谢组、突变基因定位克隆、结构生物学、转基因与基因组编辑、家蚕生物反应器、动植物活性物质提取及利用等重要的功能性研究平台，在家蚕丝蛋白合成、家蚕变态发育、免疫抗性等方面取得了世界领先的研究成果。目前，中心继续引领国际前沿，提出并开展家蚕规模种质创制研究和大科学中心建设，受到了国家和重庆市相关部门的高度重视。近年来，中心主持国家“973”计划、“863”课题、“948”项目、教育部“111”引智基地、国家自然科学基金43项(其中重点项目2项)，省部级项目200余项，在Science、Nature Biotechnology、Nature Ecology & Evolution 、PNAS、Nucleic Acids Research、Genome Research、Annual Review of Entomology、PLoS Pathogens等期刊发表研究论文600余篇，获授权专利80余项，出版《蚕的基因组》、《家蚕功能基因组研究》等专著5部， 获国家自然科学二等奖（第1完成人），重庆市自然科学奖一等奖（2项），二等奖、三等奖、日本蚕丝学会特别奖、桑麻纺织科技大奖、中国第九届青年科技奖、中国高校十大科技进展、爱思唯尔2019/2020/2021/2022/2023“中国高被引学者”、重庆市杰出英才奖等奖励或荣誉。
中心高度重视人才培养，建有“生物学”、“畜牧学”博士点，年招收博士生、硕士生及博士后70 余名。目前，博士、硕士、博士后等人数达260余人。近5 年，获重庆市优秀博士和优秀硕士论文10余篇，到国外知名大学升造和合作研究100余人，为国家培养了一批高层次创新性人才。由中心博士生党员组成的“家蚕基因组生物学国家重点实验室博士生第一党支部”获批全国党建工作样板支部培育单位。
中心着力蚕桑产业创新发展，助推乡村振兴。瞄准蚕桑生产省力化、机械化、智能化、规模化的发展方向，从品种改良、饲喂方式、采收模式、产业链条等多层面进行分析与实践，探索并逐渐完善了智能蚕桑生产系统和新型蚕丝生产工艺，受到行业内外的高度关注，在重庆、四川、云南等地区开展逐步推广示范，相关模式将促进和推动我国蚕桑丝绸产业发展和转型升级。
中心重视科普事业，创立“丝国传奇”公益科普微信号，运行6年来已成为国内蚕业界最热公众号；创办了西南大学“丝国传奇”工作坊和科普队，入选西南大学网络文化建设“111”工程。以严谨的科学态度、原创的方式推出蚕丝科普文创产品，已推送原创科普文400余篇，累计阅读量150余万次；开发相关文创产品60余份；开发“小小科学家成长记”饲料养蚕实践套盒、《创新性饲料养蚕劳动教育课程》3册，策划实施大型系列公益科普活动80余场；2021年代表重庆市参加“国家‘十三五’科技创新成就展”并入选科普展区“重点展品”，向国家领导人汇报；2023年代表重庆市赴京参加“第二届大国工匠创新交流会”；研发跨学科科普走进历史文化名校“北京市八一学校”；科普活动遍及重庆、北京、上海、四川等多省市，远达俄罗斯，受益学生累计超过6万人次。
中心地址：重庆市北碚区天生路2号 西南大学（南区）蚕学宫
联系电话：68250099
Brief Introduction
Biology Research Center of Southwest University is an Institute for Advanced Interdisciplinary Studies. It was established in August 2018 in accordance with the general requirement of national "Double First-Class" initiative. The purpose of the Center is to foster original innovation and conduct pioneering research by exploring the frontiers of life science and integrating the strength and mission of Southwest University.
Possessing the vision for the strategic, global and prospective influence that life science is making, the Center aims to solve the problems with great significance, and carry forward the long-term goal of “science development, technology innovation, industry revitalization and culture promotion”. It undertakes many important projects, including the discipline construction of "Double First-Class" initiative, development of biology disciplines, and construction of West China (Chongqing) innovation center, promoting its position as a leader and pioneer in technology innovation of related industries.
The Center is an important part of the State Key Laboratory of Silkworm Genome Biology, and has several research platforms, including Chongqing Key Laboratory of Sericulture, Chongqing Engineering Research Center of Novel Silk Materials, Chongqing Engineering Laboratory of Silkworm and Mulberry Functional Genomics and Biotechnology. There are 44 full-time faculty members in the Center, including 15 professors, 17 associate professors, 2 research associates, 6 postdocs and 4 administrative staffs. They have received many national honors for their outstanding achievements, including "Leading Talents" of the National Key Talents Plan (1), "Foreign Expert" (1), "Young Expert" (3), “Municipal Talents” such as Excellent Scientist of Chongqing, Liangjiang Scholar, Hundred Talents Plan of Chongqing, Bayu Scholar, and Young Top-notch Talents (10). The research group has also been awarded the Innovation Team of the Ministry of Education, the Innovative Team of Outstanding Scientific Research Talents of the Ministry of Agriculture, the Innovative Group of Chongqing Natural Science Foundation, and the Excellent Graduate Supervisor Team of Chongqing. The research space is over 3,000 m2, and equipped with state-of-the-art instruments, such as confocal microscope, flow cytometer, liquid mass spectrometer, with a total value of more than 60 million RMB.
Powered by the spirit of pioneering and innovating, the Center has successfully completed silkworm genome draft map, fine map and genetic variation map, built silkworm gene expression, proteomic and metabolic profiles, characterized the molecular function of silkworm important economic traits, created transgenic silkworm varieties, and established silkworm gene editing techniques for silkworm strain innovation. The research covers a variety of scientific topic, including regulation of silk protein synthesis, structural performance of silk protein, development of novel silk fiber materials, the insect hormone regulation and nutrition signal, silkworm immune mechanism and disease-resistant strain breeding, genetic manipulation and genetic material improvement, molecular mechanism of silkworm sex determination, and comparative genomics. It has established research platforms for bioinformatics, silkworm genomics, proteomics, metabolomics, positional cloning, structural biology, transgenic and genome editing, silkworm bioreactor, and bioactive substances extraction and utilization from animals and plants. In the areas of silk protein synthesis, silkworm metamorphosis development and immunity, the Center has made world-leading discoveries. Now standing on the international frontier, the Center proposes and conducts a large-scale silkworm strain innovation project, and leads the construction of a “Big Science” center, which has received high attention and support from the municipal government. In recent years, the Center has been funded by many research grants, including the national "973" program, "863" project, "948" project, the Ministry of Education "111" Wisdom Introduction Base, the National Natural Science Foundation of China (43 grants in total, including 2 key projects), and more than 200 provincial and ministerial level projects. So far, the Center has published more than 600 research papers in top journals, including Science, Nature Biotechnology, Nature Ecology & Evolution, PNAS, Nucleic Acids Research, Genome Research, Annual Review of Entomology, and PLoS Pathogens, 5 monographs including "Silkworm Genome", and been granted more than 80 patents. It has been awarded the Second Prize in National Natural Science (1st achiever), two First Prizes in Natural Science of Chongqing Municipal, Special Prize of Japanese Sericulture Society, Science and Technology Award in Silk&Linen Textile Industry, the Ninth China Youth Science and Technology Award, Top-10 Scientific Discoveries in Chinese Universities, and Elsevier’s Chinese Most Cited Researchers of 2019/2020/2021/2022/2023.
The Center has placed great emphasis on talents cultivation, and established doctoral programs in biology and animal husbandry, recruiting more than 70 graduate students and postdocs every year. At present, nearly 200 graduate students and postdocs are studying in the Center. In the past 5 years, more than ten students have been awarded Chongqing Excellent Doctor or Master Dissertation. More than 100 students have been granted the opportunity to conduct collaborative projects in world-famous universities abroad, and many of them have become high-level innovative talents. "The First Party Branch of the State Key Laboratory of Silkworm Genome Biology", composed of doctoral students of the Center, was honored the model branch cultivation unit for national Party-building activity.
The Center focuses on innovation and development of sericulture industry to promote rural revitalization. To develop labor-saving, mechanized, intelligentized mass production, the Center has studied, analyzed and improved every aspect in sericulture, from silkworm strain breeding, larva feeding, cocoon harvesting to silk textile manufacturing. Now it has successfully built the “smart silkworm feeding system” and developed novel silk manufacture technology, which has received great attention both inside and outside of silk industry. This new model of silkworm feeding and silk production has been gradually popularized in Chongqing, Sichuan, Yunnan and other regions, promoting the development and transformation of China's silk industry.
The Center attaches great importance to science popularization. It has established the WeChat account of popular science, "Legend of Silk Country", which has become the most popular account in sericulture industry in recent 5 years, and founded the "Legend of Silk Country" workshop of Southwest University, which was selected into the "111" Project of Internet Culture Construction of Southwest University. With a rigorous scientific attitude and innovative mind, "Legend of Silk Country" has published over 400 original popular science articles with more than 1.5 million hits, and developed over 60 pieces of cultural and creative silk products, including the silkworm breeding package, "Little Scientist's Growth Diary". The workshop also held over 80 public activities for popular science in Chongqing, Beijing, Shanghai and Sichuan provinces, with more than 60,000 students attended.
发展科学 革新技术 振兴产业 弘扬文化
biosci.swu.edu.cn