程道军

教授，博士生导师

西南大学前沿交叉学科研究院生物学研究中心 副主任

国家重要人才计划领军人才

科技部中青年科技创新领军人才

重庆市“巴渝学者”特聘教授

学习工作经历

2023-至今  西南大学前沿交叉学科研究院生物学研究中心 副主任

2018-2023  西南大学家蚕基因组生物学国家重点实验室    副主任

2015-至今  西南大学  研究员

2011-2012 哈佛大学医学院遗传系  访问学者

2008-2015 西南大学  副研究员

2003-2008 西南大学/西南农业大学  助理研究员

1994-2003  西南农业大学  实验师

2005-2008 西南大学  博士生

2000-2003 西南农业大学  硕士生

荣誉获奖

2021  国家重要人才计划领军人才

2021  科技部中青年科技创新领军人才

2020  重庆市自然科学二等奖（第一完成人）

2019  重庆市学术技术带头人

2017  重庆市“巴渝学者”特聘教授

研究方向

1. 家蚕激素的合成生物学及信号转导

2. 家蚕生长发育性状的分子调控机理

3. 家蚕丝腺分化发育与蚕丝蛋白合成

4. 家蚕遗传操作技术与性状遗传改良

学术贡献

主要从事家蚕遗传学与发育生物学研究，并利用果蝇模型研究昆虫生长发育与代谢稳态调控。先后主持国家自然科学基金、重庆市自然科学基金等项目10余项，并主研973计划、863计划、国家自然科学基金重点、重庆市自然科学基金创新群体等项目。作为通讯作者及第一作者在PNAS、Nucleic Acids Research、Cell Reports、J Biol Chem、Insect Biochem Mol Biol等国际知名期刊发表论文，作为主要合作者在Science、Cell metabolism、Genome Biology等国际知名期刊发表成果。参编《蚕的基因组》《蚕体解剖生理生学》《中国蚕种学》等专著，获授权发明专利3项。所指导的研究生多人次荣获重庆市优秀博士/硕士学位论文等荣誉称号。

学术兼职

2020-至今  Frontiers in Physiology编委（Topic Editor）

2020-至今  Frontiers in Endocrinology编委（Review Editor）

2020-至今  Frontiers in Insect Science编委（Review Editor）

2018-至今  中国昆虫学会昆虫生理生化与分子生物学专业委员会委员

2015-至今  全国生物芯片标准化技术委员会委员

2015-至今  重庆市生物化学与分子生物学学会理事

代表性论文

[1] Li Z#, Qian W#, Song W, Zhao T, Yang Y, Wang W, Wei L, Zhao D, Li Y, Perrimon N*, Xia Q*, Cheng D*. A salivary gland-secreted peptide regulates insect systemic growth. Cell Rep, 2022, 38(8):110397

[2] Yang Y#, Zhao T#, Li Z, Qian W, Peng J, Wei L, Yuan D, Li Y, Xia Q*, Cheng D*. Histone H3K27 methylation-mediated repression of Hairy regulates insect developmental transition by modulating ecdysone biosynthesis. PNAS, 2021, 118(35): e2101442118

[3] Qian W#, Li Z#, Song W, Zhao T, Wang W, Peng J, Wei L, Xia Q*, Cheng D*. A novel transcriptional cascade is involved in Fzr-mediated endoreplication. Nucleic Acids Res, 2020, 48(8):4214-4229

[4] Zhang T#, Song W#, Li Z#, Qian W, Wei L, Yang Y, Wang W, Zhou X, Meng M, Peng J, Xia Q*, Perrimon N*, Cheng D*. Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes. PNAS, 2018, 115(15):3960-3965

[5] Qian W, Yang Y, Li Z, Wu Y, He X, Li H, Cheng D*. Enhanced Myc expression in silkworm silk gland promotes DNA replication and silk production. Insects, 2021, 12(4):361

[6] Guo M#, Qian W#, He X, Peng J, Wang P, Wang W, Xia Q, Cheng D*. Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori. Insect Sci, 2021, 28(6):1530-1540

[7] Wang P, Qian W, Wang W, Guo M, Xia Q, Cheng D*. Identification and characterization of the Anillin gene in silkworm. DNA Cell Biol, 2019, 38(6):532-540

[8] Wang W, Peng J, Li Z, Wang P, Guo M, Zhang T, Qian W, Xia Q, Cheng D*. Transcription factor E93 regulates wing development by directly promoting Dpp signaling in Drosophila. Biochem Biophys Res Commun, 2019, 513(1):280-286

[9] Qian W, Gang X, Zhang T, Wei L, Yang X, Li Z, Yang Y, Song L, Wang P, Peng J, Cheng D*, Xia Q*. Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity. J Biol Chem, 2017, 292(30):12460-12470

[10] Gang X, Qian W, Zhang T, Yang X, Xia Q, Cheng D*. Aurora B kinase is required for cell cycle progression in silkworm. Gene, 2017, 599:60-67

[11] Meng M, Cheng D*, Peng J, Qian W, Li J, Dai D, Zhang T, Xia Q*. The homeodomain transcription factors Antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm. J Biol Chem, 2015, 290(40):24438-52

[12] Meng M, Liu C, Peng J, Qian W, Qian H, Tian L, Li J, Dai D, Xu A, Li S, Xia Q*, Cheng D*. Homeodomain protein Scr regulates the transcription of genes involved in juvenile hormone biosynthesis in the silkworm. Int J Mol Sci, 2015, 16(11):26166-85

[13] Qian W, Kang L, Zhang T, Meng M, Wang Y, Li Z, Xia Q, Cheng D*. Ecdysone receptor (EcR) is involved in the transcription of cell cycle genes in the silkworm. Int J Mol Sci, 2015,16(2):3335-49

[14] Cheng D, Qian W, Wang Y, Meng M, Wei L, Li Z, Kang L, Peng J, Xia Q*. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1. PLoS One, 2014, 9(10): e109111

[15] Cheng D, Meng M, Peng J, Qian W, Kang L, Xia Q*. Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects. Genet Mol Biol, 2014, 37(2):444-59

[16] Cheng D, Qian W, Meng M, Wang Y, Peng J, Xia Q*. Identification and expression profiling of the BTB domain-containing protein gene family in the silkworm, Bombyx mori. Int J Genomics, 2014, 2014:86506

[17] Cheng D, Peng J, Meng M, Wei L, Kang L, Qian W, Xia Q*. Microarray analysis of the juvenile hormone response in larval integument of the silkworm, Bombyx mori. Int J Genomics, 2014, 2014:426025

[18] Cheng D, Xia Q*, Duan J, Wei L, Huang C, Li Z, Wang G, Xiang Z. Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression. Insect Biochem Mol Biol, 2008,38(12):1130-1137

[19] Cheng D, Xia Q*, Zhao P, Wang Z, Xu H, Li G, Lu C, Xiang Z. EST-based profiling and comparison of gene expression in the silkworm fat body during metamorphosis. Arch Insect Biochem Physiol, 2006, 61(1):10-23

[20] Li Z#, Cheng D#, Wei L, Zhao P, Shu X, Tang L, Xiang Z, Xia Q*. The silkworm homolog of Methoprene-tolerant (Met) gene reveals sequence conservation but function divergence. Insect Sci, 2010,17(4):313-324

[21] Song W, Cheng D, Hong S, Sappe B, Hu Y, Wei N, Zhu C, O'Connor MB, Pissios P, Perrimon N. Midgut-derived activin regulates glucagon-like action in the fat body and glycemic control. Cell Metab, 2017, 25(2):386-399

[22] Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, et al. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol, 2007, 8(8): R162

[23] Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, et al. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol, 2010, 28(5):516-520

[24] Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, et al. (2009) Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science, 2009, 326(5951): 433-436

[25] Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 2004, 306 (5703):1937-1940

联系方式

E-mail：chengdj@swu.edu.cn