侯  勇

      教授，博士生导师

      西南大学前沿交叉学科研究院生物学研究中心  副主任

     学习工作经历

     1998-2002    河北农业大学本科生

     2002-2007    西南农业大学博士生（硕博连读）

     2007-2017    西南大学副教授

     2017-至今     西南大学教授    博士生导师

     2023-至今     西南大学前沿交叉学科研究院生物学研究中心  副主任

     研究领域

    以昆虫生长及变态发育机制为研究方向，以家蚕贮藏蛋白SPs、cathepsin-L、p37k蛋白酶、羧肽酶、CPAP3型表皮蛋白等为靶标，利用组学手段对变态发育时期的家蚕表皮、血液、蜕皮液、消化液等样品进行分析，同时开展基因功能研究，先后在Insect Biochemistry and Molecular Biology、Proteomics、Insect Science、Protein Science、Journal of General Virology、International Journal of Molecular Sciences、Biochemical and Biophysical Research Communications、Bioscience  Biotechnology and Biochemistry、 Proteome Science、DNA Sequence、中国农业科学、生物工程学报、蚕业科学等杂志发表论文30余篇，主持国家自然科学基金面上项目、国家自然科学基金青年项目、重庆市自然科学基金、教育部中央高校重点项目、烟草重大专项（子课题）等项目10余项，培养博士研究生3人，硕士研究生19人。担任Insect Biochemistry and Molecular Biology、Insect science、Gene、蚕业科学等多篇杂志审稿人, 任教育部学位论文评审专家。

     成果情况

代表性论文/论著：

1. Yang L, Cheng Y, Wang Q, Dong H, Shen T, Gong J, Xia Q, Hou Y*.  Distinct enzyme activities of serine protease p37k in silkworm midgut and molting fluid. Int J Biol Macromol. 2024, 61:129778.

2. Yan J, Xue Z, Dong H, Pang J, Liu H, Gong J, Xia Q, Hou Y*. Nutrition regulates the expression of storage proteins in Bombyx mori via insulin-like/FoxO signaling pathway. Insect Biochem Mol Biol. 2022,149:103847.

3. Hou Y, Yang L, Xu S, Zhang Y, Cheng Y, Li Y, Gong J, Xia Q*. Trypsin-type serine protease p37k hydrolyzes CPAP3-type cuticle proteins in the molting fluid of the silkworm Bombyx mori. Insect Biochem Mol Biol. 2021, 137:103610.

4. Li ZL, Tian S, Yang H, Zhou X, Xu SP, Zhang ZY, Gong J, Hou Y*, Xia QY. Genome-wide identification of chitin-binding proteins and characterization of BmCBP1 in the silkworm, Bombyx mori.  Insect Sci. 2019, 26(3):400-412.

5. Proteomic Analysis of the Midgut Contents of Silkworm in the Pupal Stage. Wang Q, Yang L, Tian T, Sun Y, Dong H, Gong J, Hou Y*. Insects. 2023, 14(12):953.

6. Yang H, Zhang R, Zhang Y, Liu Q, Li Y, Gong J, Hou Y*. Cathepsin-L is involved in degradation of fat body and programmed cell death in Bombyx mori. Gene. 2020, 760:144998.

7. Zhang Z, Yan J, Liu Q, Zhang Y, Gong J, Hou Y*. Genome-Wide Analysis and Hormone Regulation of Chitin Deacetylases in Silkworm. Int J Mol Sci. 2019, 4; 20(7).

8. Yang H, Li J, Liu Q, Zhang Z, Gong J, Hou Y*. Purification and characterization of two cysteine proteinase inhibitors from silkworm, Bombyx mori. Biochem Biophys Res Commun. 2018,503(4):3108-13.

9. Tian S, Zhang Z, Zhang R, Liu Q, Xu S, Gong J, Hou Y*. Analysis of cysteine protease inhibitor gene (BmCPI) promoter activity in silkworms using bac-to-bac baculovirus systems. Biosci Biotechnol Biochem. 2018, 82(9):1488-1496. doi:doi: 10.1080/09168451.

10. Hou Y, Zhang Y, Gong J, Tian S, Li J, Dong Z, Guo C, Peng L, Zhao P*, Xia Q. Comparative proteomics analysis of silkworm hemolymph during the stages of metamorphosis via liquid chromatography and mass spectrometry. Proteomics. 2016, 16(9):1421-31.

11. Gong J, Tian S, Zhou X, Yang H, Zhu Y*, Hou Y*. Transcriptional Response of Silkworm (Bombyx mori) Eggs to O₂ or HCl Treatment. Int J Mol Sci. 2016, 17(12), pii: E1838.

12. Hou Y, Li J, Li Y, Dong Z, Xia Q, Yuan YA*. Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites. Protein Sci. 2014, 23(6):735-46.

13. Hou Y, Xia Q, Yuan YA. Crystal structure of Bombyx mori nucleopolyhedrovirus ORF75 reveals a pseudo-dimer of thiol oxidase domains with a putative substrate-binding pocket. J Gen Virol. 2012,93:2142-51

14. Hou Y, Zou Y, Wang F, Gong J, Zhong X, Xia Q, Zhao P*. Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages.  Proteome Science, 2010, 8:45

15. Hou Y, Xia Q* , Zhao P, Zou Y, Liu H, Guan J, Gong J, Xiang Z. Studies on middle silk gland and posteriorsilk gland of silkworm (Bombyx mori) using two-dimensional electrophoresis and mass spectrometry. Insect Biochemistry and Molecular Biology 2007,37:486-496.

16. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J, Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, Wan Y, Zhu Y, Yu M, Shen W, Wu D, Xiang Z, Yu J, Wang J, Li R, Shi J, Li H, Li G, Su J, Wang X, Li G, Zhang Z, Wu Q, Li J, Zhang Q, Wei N, Xu J, Sun H, Dong L, Liu D, Zhao S, Zhao X, Meng Q, Lan F, Huang X, Li Y, Fang L, Li C, Li D, Sun Y, Zhang Z, Yang Z, Huang Y, Xi Y, Qi Q, He D, Huang H, Zhang X, Wang Z, Li W, Cao Y, Yu Y, Yu H, Li J, Ye J, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li S, Ni P, Zhang J, Zhang Y, Zheng H, Mao B, Wang W, Ye C, Li S, Wang J, Wong GK, Yang H; Biology Analysis Group. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 2004, 306:1937-1940.

     联系方式

     Email：yhou@swu.edu.cn