林 英

博士，研究员，硕士生导师

西南大学前沿交叉学科研究院生物学研究中心  副主任

招生专业：发育生物学（方向：发育分子调控）和特种经济动物饲养（方向：家蚕功能基因组及应用）。

学习工作经历：

2021.06 - 至  今       西南大学                                                  研究员

2019.12 - 2020.12     英国华威大学                                         访问学者

2007.03 - 2021.06     西南大学                                                副研究员

2001.09 - 2007.01     西南大学                                                博士（硕博连读）

1997.07 - 2001.08     重庆市荣昌县河包镇人民政府                  科员

1993.09 - 1997.07     西南农业大学                                         学士

研究领域：

      主要从事关于家蚕激素、变态发育和卵形成等重要功能基因的分子调控机制研究，以及野蚕资源的收集、新型家蚕资源的创制及应用等研究工作，致力于昆虫变态期基因功能研究体系和转基因注射及筛选体系构建、“永久蛹 ”、“ 不烘茧”等家蚕新型品种的创制、开发家蚕脂肪体生物反应器、保护和应用野蚕资源、以及为生态防治鳞翅目害虫提供新思路。

成果情况：

      先后主持国家自然基金、科技重大专项子课题、重庆市自然科学基金、西南大学基本科研业务费专项资金的一般及重点等项目；作为主研人员参加了科技部“973”、“863”及国家自然科学基金重点及面上等项目。在《Science》、《nature biotechnology》、《Nat Commun》、《Genome Res》、《Sci Adv》、《Development》、《J Biol Chem》、《BBA--general subjects》等国际国内刊物上先后发表学术论文70多篇，其中 SCI论文40多篇；授权专利5项；获得重庆市自然科学二等奖2项；参与了专著《家蚕基因组》和《家蚕饲养与良种繁育学》教科书的编写。

代表性成果

1.Daniela M Riley, Randa Elsayed, Mark D Walsh, Simaran Johal, Ying Lin, Harry Walton, Till Bretschneider, Sascha Ott, Andrew C Nelson (2026) Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis. Genome Res. gr.280838.125.

2.Qingsong Liu, Mingmin He, Hao Chen, Yongfen Zhang, Wanshun Li, Xue Zhang, Xiaoyang Wang, Hongyan Li, Hongni Li, Dongsheng Ran, Zhangchen Tang, Yanan Wu, Lin Zhu, Xingju Zhang, Guoli Li, Longxing Wang, Xiangyu Cai, Jian He, Xiao Liu, Feng Xi, Linshengzhe Ji, Guibo Li, Ying Lin, Guocheng Liu, Lingyan Wang, Xun Xu, Ping Zhao, Ao Chen, Min Xie, Qingyou Xia (2026) Single-cell and spatial transcriptomics define 20E-driven developmental reprogramming in silkworm wing disc. Nat Commun. 2026 Feb 23. doi: 10.1038/s41467-026-69518-6.

3.Qingqing Linghu, Haoyun Li, Jiahui Wan, Xiaolu Zhang, Jingjing Huang, Zhiqing Li, Yuying Wang, Jianhua Xia, Zhaoming Dong, Ying Lin, Ping Zhao, Yan Zhang (2025) PBX and Dfd cooperatively regulate stage-specific expression of 30 K protein BmLP1 in Bombyx mori.Insect Mol Biol. 34(5):783-791.

4.Lingyan Wang, Kun Wang, Yinan Liu, Zhang Chuan Peng, Tong Zhang, Huawei Liu, Xiaoting Hua, Ying Lin, Qingyou Xia, Ping Zhao (2025) Bmpallidin, encoding a subunit of the BLOC-1 complex, is involved in urate granules formation in silkworm integument. Int J Biol Macromol.  295:139101.

5.Jinxin Wu, Yungui Zhang, Han Chen, Qingyou Xia, Ping Zhao, Ying Lin, Guanwang Shen (2024) The Ability to Digest Cellulose Can Significantly Improve the Growth and Development of Silkworms. Insects. 15(12):997.

6.Caijiang Xiong , Chuanyu Xiong, Jiahui Lu, Rui Long, Hanyang Jiao, Yun Li a, Bei Wang, Ying Lin, Hua Ye, Lingyun Lin, Ronghua Wu （2024）flgL mutation reduces pathogenicity of Aeromonas hydrophila by negatively regulating swimming ability, biofilm forming ability, adherence and virulence gene expression. International Journal of Biological Macromolecules 261 (2024) :129676.

7.Xueqin Mao, Dongxu Xing, Die Liu , Haoran Xu, Luyu Hou, Ping Lin, Qingyou Xia, Ying Lin,* and Guanwang Shen （2023）Ecdysteroid UDP-Glucosyltransferase Expression in Beauveria bassiana Increases Its Pathogenicity against Early Instar Silkworm Larvae. J. Fungi. 9: 987.

8.Yinying Xu, Guanwang Shen, Jinxin Wu, Xueqin Mao, Linbang Jia, Yan Zhang, Qingyou Xia, Ying Lin*（2023）Vitellogenin receptor transports the 30K protein LP1 without cell-penetrating peptide, into the oocytes of the silkworm, Bombyx mori，Front Physiol. 14: 1117505.

9.JinxinWu, Guanwang Shen, Die Liu, Haoran Xu, Mengyao Jiao, Yungui Zhang,YingLin*, and Ping Zhao*, (2022) The Response of the Estrogen-Related Receptor to 20-Hydroxy ecdysone in Bombyx mori: Insight In to the Function of Estrogen-Related Receptor in Insect 20-Hydroxyecdysone Signaling Pathway, Frontiers in Physiology, 12: e785637

10.Guanwang Shen, Jinxin Wu, Ying Lin, Xiaoting Hua, Qingyou Xia, Ping Zhao.（2021）Estrogen-Related Receptor Influences the Hemolymph Glucose Content by Regulating Midgut Trehalase Gene Expression in the Last Instar Larvae of Bombyx mori, Int J Mol Sci, 22(9):4343.

11.Yandi Zhang, Yu Yang, Guanwang Shen, Xueqin Mao, Mengyao Jiao, Ying Lin* (2020) Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae). J Insect Sci, 20(6):31-41.

12.Guanwang Shen, Haiyan Zhang, Ying Lin, Wei Long, Ping Zhao.( 2020) A novel system for separation and purification of egg pigments from the nondiapause red‐egg mutant Re‐nd in the silkworm, Bombyx mori. Archives of Insect Biochemistry and Physiology.First published: Arch Insect Biochem Physiol, 105(2):e21728.

13.Enxiang Chen, Zhiwei Chen, Shenglong Li, Dongxu Xing, Huizhen Guo, Jianqiu Liu, Xiaocun Ji, Ying Lin, Shiping Liu, Qingyou Xia. (2020 ) bmo-miR-2739 and the novel microRNA miR-167 coordinately regulate the expression of the vitellogenin receptor in Bombyx mori oogenesis. Development, 147(8): dev183723.

14.Guanwang Shen, Hongling Liu, Ying Lin, Dongxu Xing, Yujing Zhang, and Qingyou Xia. (2020) Effects of Certain cis-Regulatory Elements on Stage-Specific vitellogenin Expression in the Bombyx mori (Lepidoptera: Bombycidae). Journal of Insect Science, 20(3): 18; 1–9.

15.Long Wei, Wu J, Shen Guanwang, Zhang Haiyan, Liu Honglin, Xu Yinyin, Gu Jianjian, Jia Linbang, Lin Ying*, Xia Qingyou, (2020) Estrogen-related receptor participates in regulating glycolysis and influences embryonic development in silkworm Bombyx mori, Insect Mol Biol, 29(2):160-169.

16.Liu Honglin, Lin Ying, Gu Jianjian, Ruan Yang, Shen Guanwang, Zhang Yan, Wang Huijuan, Meng Ziwang, Li Kairong, Xia Qingyou. (2019) The increase of amino acids induces the expression of vitellogenin after spinning in the silkworm Bombyx mori. J Insect Physiol, 8(2019): 103913.

17.Liu H, Lin Y, Shen G, Gu J, Ruan Y, Wu J, Zhang Y, Li K, Long W, Jia L, Xia Q (2019) A novel GATA transcription factor GATAβ4 promotes vitellogenin transcription and egg formation in the silkworm Bombyx mori. Insect Biochem Mol Biol, 107 (2019):10-18.

18.Hongling Liu, Ying Lin, Guanwang Shen, Jianjian Gu, Haiyan Zhang, Jinxin Wu, Yinying Xu, Wei Long and Qingyou Xia (2018) Establishment of a suitable control reporter plasmid of a dual-luciferase reporter gene system for hormone research in silkworm cell lines. Chin J Biotech, 34(10): 1631−1641.

19.Yan Zhang, Dongchao Zhao, Zhu Meng, Zhaoming Dong, Ying Lin, Shiyi Chen, Qingyou Xia, and Ping Zhao. (2017) Wild Silkworm Cocoon Contains More Metabolites Than Domestic Silkworm Cocoon to Improve Its Protection. Journal of Insect Science,17(5): 105-111.

20.Haiyan Zhang, Ying Lin, Guanwang Shen, Hongling Liu, Wei Long, Xue Tan, Chao Lei, Yandi Zhang,Yinying Xu, Jinxin Wu, Jianjian Gu, Qingyou Xia, Ping Zhao (2017) Pigmentary analysis of eggs of the silkworm Bombyx mori. Journal of Insect Physiology, 101 (2017) : 142–150.

21.Ying Lin, Hongling Liu,Congwen Yang, JianjianGu, Guanwang Shen, Haiyan Zhang, Enxiang Chen, Chaoshan Han, Yandi Zhang, Yinying Xu, Jinxin Wu, Qingyou Xia (2017) The POU homeodomain transcription factor POUM2 and broad complex isoform 2 transcription factor induced by 20-hydroxyecdysone collaboratively regulate vitellogenin gene expression and egg formation in the silkworm Bombyx mori. Insect Mol Biol. 26(5):496-506.

22.Chaoshan Han, Enxiang Chen, Guanwang Shen, Zhixin Peng, Yinying Xu,Haiyan Zhang, Hongling Liu, Yandi Zhang, Jinxin Wu, Ying Lin*, Qingyou Xia ( 2017) Vitellogenin receptor selectively endocytoses female-specific and highly-expressed hemolymph proteins in the silkworm Bombyx mori. Biochem Cell Biol,  95(4):510-516.

23.Congwen Yang#, Ying Lin#, Guanwang Shen, Enxiang Chen, Yanxia Wang, Juan Luo, Haiyan Zhang, Zhixin Pen, Runmiao Xing, Qinyou Xia (2014) The feminine qualities of male: vitellogenin synthesis is induced by ovary for egg formation in male silkworm, Bombyx mori. Biochemical and Biophysical Research Communications, 453 (2014):31-36.

24.Congwen Yang, Ying Lin, Hongling Liu, Guanwang Shen, Juan Luo, Haiyan Zhang, Zhixin, Peng, Enxiang Chen, Runmiao Xing, Chaoshan Han, Qingyou Xia (2014) The Broad Complex isoform 2 (BrC-Z2) transcriptional factor plays a critical role in vitellogenin transcription in the silkworm Bombyx mori. biochimica et biophysica acta-general subjects, 1840(9): 2674-2684.

25.Ying Lin, Yan Meng, Yan-Xia Wang, Juan Luo, Susumu Katsuma, Cong-Wen Yang,Yutaka Banno, Takahiro Kusakabe, Toru Shimada, and Qing-You Xia (2013) Vitellogenin Receptor Mutation Leads to the Oogenesis Mutant Phenotype “scanty vitellin” of the Silkworm Bombyx mori. J Biol Chem, 288, (19):13345–13355.

26.Hui Xiang, Jingde Zhu, Quan Chen, Fangyin Dai, Xin Li, Muwang Li, Hongyu Zhang ,Guojie Zhang, Dong Li, Yang Dong, Li Zhao, Ying Lin, et al. (2010) Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. nature biotechnology, 28: 516–520.

27.Qingyou Xia, Yiran Guo, Ze Zhang, Dong Li, Zhaoling Xuan, Zhuo Li, Fangyin Dai,Yingrui Li, Daojun Cheng, Ruiqiang Li, Tingcai Cheng, Tao Jiang, Celine Becquet, Xun Xu, ChunLiu, Xingfu Zha, Wei Fan, Ying Lin, et al. (2009) Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx). Science, 326 (16):433-436.

28.Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha XF, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, et al. (2004) A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 306 (5703):1937-1940.

联系方式

Email：ly908@swu.edu.cn