林 英

博士，研究员，硕士生导师

西南大学前沿交叉学科研究院生物学研究中心  副主任

招生专业：发育生物学（方向：发育分子调控）和特种经济动物饲养（方向：家蚕功能基因组及应用）。

学习工作经历：

2021.06 - 至  今         西南大学                                     研究员

2019.12 - 2020.12     英国华威大学                              访问学者

2007.03 - 2021.06     西南大学                                     副研究员

2001.09 - 2007.01     西南大学                                     博士（硕博连读）

1997.07 - 2001.08     重庆市荣昌县河包镇人民政府       科员

1993.09 - 1997.07     西南农业大学                               学士

研究领域：

     主要从事关于家蚕激素、变态发育和卵形成等重要功能基因的分子调控机制研究，以及野蚕资源的收集、新型家蚕资源的创制及应用等研究工作，致力于昆虫变态期基因功能研究体系构建、“永久蛹 ”、“ 不烘茧”等家蚕新型品种的创制、开发家蚕脂肪体生物反应器、保护和应用野蚕资源、以及为生态防治鳞翅目害虫提供新思路。

成果情况：

     先后主持国家自然基金、科技重大专项子课题、重庆市自然科学基金、西南大学基本科研业务费专项资金的一般及重点等项目；作为主研人员参加了科技部“973”、“863”及国家自然科学基金重点及面上等项目。在《Science》、《nature biotechnology》、《Sci Adv》、《Development》、《J Biol Chem》、《BBA--general subjects》等国际国内刊物上先后发表学术论文近60篇，其中 SCI论文30多篇；授权专利5项；获得重庆市自然科学二等奖2项；参与了专著《家蚕基因组》和《家蚕饲养与良种繁育学》教科书的编写。

代表性论文/论著：

1.JinxinWu, Guanwang Shen, Die Liu, Haoran Xu, Mengyao Jiao, Yungui Zhang,YingLin*, and Ping Zhao*, (2022) The Response of the Estrogen-Related Receptor to 20-Hydroxy ecdysone in Bombyx mori: Insight In to the Function of Estrogen-Related Receptor in Insect 20-Hydroxyecdysone Signaling Pathway, Frontiers in Physiology, 12: e785637

2.Guanwang Shen, Jinxin Wu, Ying Lin, Xiaoting Hua, Qingyou Xia, Ping Zhao.（2021）Estrogen-Related Receptor Influences the Hemolymph Glucose Content by Regulating Midgut Trehalase Gene Expression in the Last Instar Larvae of Bombyx mori, Int J Mol Sci, 22(9):4343.

3.Yandi Zhang, Yu Yang, Guanwang Shen, Xueqin Mao, Mengyao Jiao, Ying Lin* (2020) Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae). J Insect Sci, 20(6):31-41.

4.Guanwang Shen, Haiyan Zhang, Ying Lin, Wei Long, Ping Zhao.( 2020) A novel system for separation and purification of egg pigments from the nondiapause red‐egg mutant Re‐nd in the silkworm, Bombyx mori. Archives of Insect Biochemistry and Physiology.First published: Arch Insect Biochem Physiol, 105(2):e21728.

5.Enxiang Chen, Zhiwei Chen, Shenglong Li, Dongxu Xing, Huizhen Guo, Jianqiu Liu, Xiaocun Ji, Ying Lin, Shiping Liu, Qingyou Xia. (2020 ) bmo-miR-2739 and the novel microRNA miR-167 coordinately regulate the expression of the vitellogenin receptor in Bombyx mori oogenesis. Development, 147(8): dev183723.

6.Guanwang Shen, Hongling Liu, Ying Lin, Dongxu Xing, Yujing Zhang, and Qingyou Xia. (2020) Effects of Certain cis-Regulatory Elements on Stage-Specific vitellogenin Expression in the Bombyx mori (Lepidoptera: Bombycidae). Journal of Insect Science, 20(3): 18; 1–9.

7.Long Wei, Wu J, Shen Guanwang, Zhang Haiyan, Liu Honglin, Xu Yinyin, Gu Jianjian, Jia Linbang, Lin Ying*, Xia Qingyou, (2020) Estrogen-related receptor participates in regulating glycolysis and influences embryonic development in silkworm Bombyx mori, Insect Mol Biol, 29(2):160-169.

8.Liu Honglin, Lin Ying, Gu Jianjian, Ruan Yang, Shen Guanwang, Zhang Yan, Wang Huijuan, Meng Ziwang, Li Kairong, Xia Qingyou. (2019) The increase of amino acids induces the expression of vitellogenin after spinning in the silkworm Bombyx mori. J Insect Physiol, 8(2019): 103913.

9.Liu H, Lin Y, Shen G, Gu J, Ruan Y, Wu J, Zhang Y, Li K, Long W, Jia L, Xia Q (2019) A novel GATA transcription factor GATAβ4 promotes vitellogenin transcription and egg formation in the silkworm Bombyx mori. Insect Biochem Mol Biol, 107 (2019):10-18.

10.Hongling Liu, Ying Lin, Guanwang Shen, Jianjian Gu, Haiyan Zhang, Jinxin Wu, Yinying Xu, Wei Long and Qingyou Xia (2018) Establishment of a suitable control reporter plasmid of a dual-luciferase reporter gene system for hormone research in silkworm cell lines. Chin J Biotech, 34(10): 1631−1641.

11.Yan Zhang, Dongchao Zhao, Zhu Meng, Zhaoming Dong, Ying Lin, Shiyi Chen, Qingyou Xia, and Ping Zhao. (2017) Wild Silkworm Cocoon Contains More Metabolites Than Domestic Silkworm Cocoon to Improve Its Protection. Journal of Insect Science,17(5): 105-111.

12.Haiyan Zhang, Ying Lin, Guanwang Shen, Hongling Liu, Wei Long, Xue Tan, Chao Lei, Yandi Zhang,Yinying Xu, Jinxin Wu, Jianjian Gu, Qingyou Xia, Ping Zhao (2017) Pigmentary analysis of eggs of the silkworm Bombyx mori. Journal of Insect Physiology, 101 (2017) : 142–150.

13.Ying Lin, Hongling Liu,Congwen Yang, JianjianGu, Guanwang Shen, Haiyan Zhang, Enxiang Chen, Chaoshan Han, Yandi Zhang, Yinying Xu, Jinxin Wu, Qingyou Xia (2017) The POU homeodomain transcription factor POUM2 and broad complex isoform 2 transcription factor induced by 20-hydroxyecdysone collaboratively regulate vitellogenin gene expression and egg formation in the silkworm Bombyx mori. Insect Mol Biol. 26(5):496-506.

14.Chaoshan Han, Enxiang Chen, Guanwang Shen, Zhixin Peng, Yinying Xu,Haiyan Zhang, Hongling Liu, Yandi Zhang, Jinxin Wu, Ying Lin*, Qingyou Xia ( 2017) Vitellogenin receptor selectively endocytoses female-specific and highly-expressed hemolymph proteins in the silkworm Bombyx mori. Biochem Cell Biol,  95(4):510-516.

15.Congwen Yang#, Ying Lin#, Guanwang Shen, Enxiang Chen, Yanxia Wang, Juan Luo, Haiyan Zhang, Zhixin Pen, Runmiao Xing, Qinyou Xia (2014) The feminine qualities of male: vitellogenin synthesis is induced by ovary for egg formation in male silkworm, Bombyx mori. Biochemical and Biophysical Research Communications, 453 (2014):31-36.

16.Congwen Yang, Ying Lin, Hongling Liu, Guanwang Shen, Juan Luo, Haiyan Zhang, Zhixin, Peng, Enxiang Chen, Runmiao Xing, Chaoshan Han, Qingyou Xia (2014) The Broad Complex isoform 2 (BrC-Z2) transcriptional factor plays a critical role in vitellogenin transcription in the silkworm Bombyx mori. biochimica et biophysica acta-general subjects, 1840(9): 2674-2684.

17.Ying Lin, Yan Meng, Yan-Xia Wang, Juan Luo, Susumu Katsuma, Cong-Wen Yang,Yutaka Banno, Takahiro Kusakabe, Toru Shimada, and Qing-You Xia (2013) Vitellogenin Receptor Mutation Leads to the Oogenesis Mutant Phenotype “scanty vitellin” of the Silkworm Bombyx mori. J Biol Chem, 288, (19):13345–13355.

18.Hui Xiang, Jingde Zhu, Quan Chen, Fangyin Dai, Xin Li, Muwang Li, Hongyu Zhang ,Guojie Zhang, Dong Li, Yang Dong, Li Zhao, Ying Lin, et al. (2010) Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. nature biotechnology, 28: 516–520.

19.Qingyou Xia, Yiran Guo, Ze Zhang, Dong Li, Zhaoling Xuan, Zhuo Li, Fangyin Dai,Yingrui Li, Daojun Cheng, Ruiqiang Li, Tingcai Cheng, Tao Jiang, Celine Becquet, Xun Xu, ChunLiu, Xingfu Zha, Wei Fan, Ying Lin, et al. (2009) Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx). Science, 326 (16):433-436.

20.Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha XF, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, et al. (2004) A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 306 (5703):1937-1940.

联系方式

Email：ly908@swu.edu.cn