王 峰
理学博士，研究员，硕士生导师
重庆市巴渝青年学者（2021）
重庆市蚕丝纤维新材料工程技术研究中心 副主任
一、 教育与工作经历
2023年---至 今，西南大学，研究员
2018年---2023年，西南大学，副教授
2018年---2019年，美国塔夫茨大学（Tufts University, U.S.），访问学者
2016年---2018年，西南大学，助理研究员
2014年---2016年，西南大学，师资博士后
2008年---2014年，西南大学，理学博士
2004年---2008年，西南大学，工学学士
二、研究领域
1. 家蚕丝腺合成生物学与蛋白药物研发
2. 医用生物材料的开发与组织工程应用
3. 蚕丝固定化酶技术研发以及产品开发
三、研究内容
长期致力于家蚕丝腺生物反应器与蚕丝遗传改良探索研究，积极推动家蚕及蚕丝在生物制药和生物材料领域中的创新应用。
1、突破了家蚕丝腺生物反应器表达效率的瓶颈，优化建立了高效稳定的家蚕丝腺生物反应器合成系统，培育出高效表达人血清白蛋白、人乳铁蛋白、人源生长因子、人胰岛素等高附加值药用蛋白的新型家蚕素材品系50余个；建立了蚕丝中外源蛋白的规模化分离纯化技术体系，纯化获得多个毫克级高纯度具有生物活性的重组蛋白，并完成其生物活性评价，证明家蚕丝腺具备合成功能性外源蛋白的能力，为家蚕丝腺生物反应器用于生物制药和市场转化奠定了理论基础和技术保障。
2、建立了蚕丝遗传改良关键技术体系，创新利用家蚕丝腺规模化生物合成功能性蚕丝原料，利用具有组织修复功能的20余种人源生长因子，以及具有抗肿瘤、抗氧化、抑制炎症等功能的10余种治疗性重组蛋白对蚕丝进行遗传改良，建立了可稳定遗传的新型蚕丝家蚕素材品系库。建立了功能性蚕丝生物材料制备技术，研发了具有促进组织修复功能的蚕丝膜、水凝胶和3D支架等生物材料，并在治疗子宫内膜粘连，唇腭裂修复，定向成骨分化，血管修复，结肠炎治疗，免疫力提升等医学动物模型中展现优异的疗效。相关成果得到央视和市级媒体的广泛报道，并引起多家投资企业和医疗机构的高度关注。
3、以第一作者/通讯作者或参与者在Acta Biomaterialia（5次），ACS Appl Mater & Interfaces，Biomaterials Science（封面论文），Biosensors and Bioelectronics等生物材料Top期刊上发表SCI论文50余篇，引用次数超过1200次。拥有国家发明专利10余项，专利转让5项。主持包括国家自然科学基金在内的科研项目10余个。获2017年重庆市自然科学奖二等奖，2021年重庆市巴渝青年学者等奖项和称号。多次受邀赴欧美，亚太及国内多所著名高校做学术报告，与国际国内蚕丝研究顶级团队建立了长期稳定的合作关系。受邀担任Biomaterials，Chemical Communications等十余个著名期刊审稿人。
四、发表论文 (Updated by Sep. 2023)
1. First author, Co-first author (#), or corresponding author (*) publications
(17) Feng Wang1, Ri-Yuan Wang1, De-Bin Zhong2, Ping Zhao1, Qing-You Xia1*. Highly efficient expression of human extracellular superoxide dismutase (rhEcSOD) with ultraviolet-B-induced damage-resistance activity in transgenic silkworm cocoons. Insect Science. 2023, 0, 1-15.
https://doi.org/10.1111/1744-7917.13289
(16) Huanhuan Tan,1 Yanting Ji,1 Hexu Lei,1 Fangyu Wang,1 Huan Dong,1 Shifeng Yang,1 Hongji Zhou,1 Hanxin Deng,1 Siyu Chen,1 David L. Kaplan,2 Qingyou Xia,1* Feng Wang1*. Large-scale and cost-effective production of recombinant human serum albumin (rHSA) in transgenic Bombyx mori cocoons. International Journal of Biological Macromolecules. 2023, 245, 125527.
https://doi.org/10.1016/j.ijbiomac.2023.125527
(15) Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, Qingyou Xia*, Feng Wang*. Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression. ACS Appl Mater Interfaces. 2021, 13(38): 45175-45190
https://doi.org/10.1021/acsami.1c08409
(14) Feng Wang#, Chengchen Guo#, Qianqian Yang, Chunmei Li, Ping Zhao, Qingyou Xia∗, David L. Kaplan∗. Protein composites from silkworm cocoons as versatile biomaterials. Acta Biomaterialia. 2021, 121: 180–192.
(13) Feng Wang*, Yan-Ting Ji, Chi Tian, Yuan-Cheng Wang, Shen Xu, Ri-Yuan Wang,Qian-Qian Yang, PingZhao, Qing-You Xia*. An inducible constitutive expression system in Bombyx mori mediated by phiC31 integrase. Insect Science. 2021, 28(5), 1277-1289.
https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-7917.12866
(12) Feng Wang, Kai Hou, Wenjing Chen, Yuancheng Wang, Riyuan Wang, Chi Tian, Sheng Xu, Yanting Ji, Qianqian Yang, Ping Zhao, Ling Yu, Zhisong Lu, Huijie Zhang, Fushu Li, Han Wang, Baicheng He, David L. Kaplan*, Qingyou Xia*. Transgenic PDGF-BB/sericin hydrogel supports for cell proliferation and osteogenic differentiation. Biomaterials Science, 2020, 8(2), 657-672.
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm01478k#!divAbstract
(11) Yuancheng Wang, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ling Yu, Zhisong Lu, Ping Zhao, Qingyou Xia*, Feng Wang*. Genetic Fabrication of Functional Silk Mats with Improved Cell Proliferation Activity for Medical Application. Biomaterials Science, 2019,7, 4536-4546. (Inside front cover)
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm01285k/unauth#!divAbstract
(10) Feng Wang, Yuancheng Wang, Chi Tian, Sheng Xu, Riyuan Wang, Kai Hou, Wenjing Chen, Ping Zhao, Ling Yu, Zhisong Lu, David L.Kaplan*, Qingyou Xia*. Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk. Acta Biomaterialia, 2018,79: 239-252.
https://www.sciencedirect.com/science/article/pii/S1742706118304987
(9) Feng Wang, Riyuan Wang, Yuancheng Wang, Ping Zhao, Qingyou Xia*. Large-scale production of bioactive recombinant human acidic fibroblast growth factor in transgenic silkworm cocoons. Scientific Reports. 2015, 5:16323.
http://www.nature.com/articles/srep16323
(8) Feng Wang, Riyuan Wang, Yuancheng Wang, Hanfu Xu, Sanyuan Ma, Lin Yuan, Huan Ding, Ping Zhao, Qingyou Xia*. Remobilizing deleted piggyBac vector post integration for transgene stability in silkworm. Mol Genet Genomics. 2015, 290 (3):1181-1189.
http://link.springer.com/article/10.1007/s00438-014-0982-6
(7) Feng Wang, Hanfu Xu, Yuancheng Wang, Riyuan Wang, Lin Yuan, Huan Ding, Chunnuan Song, Zhixin Peng, Zhangchuan Peng, Sanyuan Ma, Ping Zhao, Qingyou Xia*. Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application. Acta Biomaterialia, 2014, 10(12): 4947-4955.
http://www.sciencedirect.com/science/article/pii/S1742706114002876
(6) Feng Wang, Hanfu Xu, Lin Yuan, Sanyuan Ma, Yuancheng Wang, Xiaoli Duan, Jianping Duan, Zhonghuai Xiang, Qingyou Xia*. An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands of transgenic silkworms. Transgenic Res. 2013, 22(5): 925-38.
http://link.springer.com/article/10.1007/s11248-013-9695-6
(5) Feng Wang, Sanyuan Ma, Hanfu Xu, Jianping Duan, Yuancheng Wang, Huan Ding, Yuanyuan Liu, Xiaogang Wang, Ping Zhao, Qingyou Xia*. High-efficiency system for construction and evaluation of customized TALENs for silkworm genome editing. Mol Genet Genomics. 2013, 288(12):683-90.
http://link.springer.com/article/10.1007/s00438-013-0782-4
(4) Yuancheng Wang#, Feng Wang#, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Fan Wang, Ling Yu, Zhisong Lu, Ping Zhao, Qingyou Xia *. Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application. Acta Biomaterialia. 2019, 86, 148-157.
https://www.sciencedirect.com/science/article/pii/S174270611830761X
(3) Yuancheng Wang#, Feng Wang#, Sheng Xu, Riyuan Wang, Wenjing Chen, Kai Hou, Chi Tian, Fan Wang, Ping Zhao, Qingyou Xia*. Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm. Molecular Genetics and Genomics. 2019, 294: 849-859.
https://doi.org/10.1007/s00438-019-01534-2
(2) Sheng Xu#, Feng Wang#, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia*. A silkworm based silk gland bioreactor for high-efficiency production of recombinant human lactoferrin with antibacterial and anti-inflammatory activities. Journal of Biological Engineering, 2019,13:61.
https://doi.org/10.1186/s13036-019-0186-z
(1) Yuancheng Wang#, Feng Wang#, Riyuan Wang, Ping Zhao, Qingyou Xia*. 2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori. Scientific Reports. 2015, 5:16273.
http://www.nature.com/articles/srep16273
2. Joint-publications
(29) Rongwei Gao, Xuelian Yang, Qiuju Yang, Yuanke Wu, Feng Wang, Qingyou Xia & Shu-Juan Bao*. Design of an amperometric glucose oxidase biosensor with added protective and adhesion layers. Microchimica Acta, 2021, 188, 312.
(28) Weizhen Sun, Caroline S. Taylor, Yi Zhang, David A. Gregory, Mhd Anas Tomeh, John W. Haycock, Patrick J. Smith, Feng Wang, Qingyou Xia, Xiubo Zhao*. Cell guidance on peptide micropatterned silk fibroin scaffolds. Journal of Colloid and Interface Science. 2021, 603: 380–390.
(27) Xiaobai Li, Linxiang Wang, Gang Xiao, Yan Qiao, Feng Wang, Qingyou Xia, Ling Yu*, Zhisong Lu*. Adhesive tape-assisted etching of silk fibroin film with LiBr aqueous solution for microfluidic devices. Materials Science & Engineering C. 2021, 118: 111543.
(26) Yuancheng Wang, Feng Wang, Sheng Xu, Riyuan Wang, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao, Qingyou Xia*. Transdermal peptide conjugated to human connective tissue growth factor with enhanced cell proliferation and hyaluronic acid synthesis activities produced by a silkworm silk gland bioreactor. Applied Microbiology and Biotechnology (2020) 104:9979–9990.
(25) Jingjing Fu, Xiao Bai Li, Lin Xiang Wang, Xiao Hui Lv, Zhisong Lu, Feng Wang, Qingyou Xia, Ling Yu* and Chang Ming Li*. One-Step Dip-Coating-Fabricated Core–Shell Silk Fibroin Rice Paper Fibrous Scaffolds for 3D Tumor Spheroid Formation. ACS Appl. Bio Mater. 2020, 3, 7462−7471.
(24) Ying Wang, Deng Wang, Li-Hong Sun, Long-Cheng Zhang, Zhi-Song Lu, Peng Xue, Feng Wang, Qing-You Xia, and Shu-Juan Bao*. BC@DNA-Mn3(PO4)2 Nanozyme for Real-Time Detection of Superoxide from Living Cells. Anal. Chem. 2020, 92, 24, 15927–15935
(23) Yan Fang Cheng, Yi Hong Mei, Gnanasekar Sathishkumar, Zhi Song Lu,⁎, Chang Ming Li, Feng Wang, Qing You Xia, Li Qun Xu*. Tannic acid-assisted deposition of silk sericin on the titanium surfaces for antifouling application. Colloid and Interface Science Communications. 2020, 35, 100241.
(22) Gang Xiao, Jing He, Yan Qiao, Feng Wang, Qingyou Xia, Xin Wang, Ling Yu*, Zhisong Lu* & Chang-Ming Li. Facile and Low-Cost Fabrication of a Thread/Paper-Based Wearable System for Simultaneous Detection of Lactate and pH in Human Sweat. Advanced Fiber Materials. 2020, 2: 265-278.
(21) Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, Tang Z, Cheng X, Yang Y, Xu L, Xia Q. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations. Molecules. 2019 Nov 20;24(23):4217. doi: 10.3390/molecules24234217.
(20) Zhangchuan Peng; Xi Yang; Chun Liu; Zhaoming Dong; Feng Wang; Xin Wang; Wenbo Hu; Xia Zhang; Ping Zhao; Qingyou Xia*. Structural and Mechanical Properties of Silk from Different Instars of Bombyx mori. Biomacromolecules, 2019, 20 (3), pp 1203–1216. https://pubs.acs.org/doi/10.1021/acs.biomac.8b01576
(19) Ying Wang, Deng Wang, Li-Hong Sun, Peng Xue, Min-Qiang Wang, Zhisong Lu, Feng Wang, Qingyou Xia, Mao-Wen Xu, Shu-Juan Bao*. Constructing high effective nano-Mn3(PO4)2-chitosan in situ electrochemical detection interface for superoxide anions released from living cell. Biosensors and Bioelectronics. Volume 133, 15 May 2019, Pages 133-140. https://www.sciencedirect.com/science/article/pii/S0956566319302325?dgcid=coauthor
(18) Lina Liu, Yejing Wang, Yu Li, Pengchao Guo, Chun Liu, Zhiqing Li, Feng Wang, Ping Zhao, Qingyou Xia, Huawei He*. Insights into the repression of fibroin modulator binding protein-1 on the transcription of fibroin H-chain during molting in Bombyx mori. Insect Biochem Mol Biol. Volume 104, January 2019, Pages 39-49.
https://www.sciencedirect.com/science/article/pii/S0965174818302996
(17) Ying Zhou, Jing-Jing Fu, Lin-Xiang Wang, Zhisong Lu, Feng Wang, Qingyou Xia, Yuejun Kang, Chang Ming Li & Ling Yu*. Freeze-drying prepared ready-to-use gelatin @polypropylene nonwoven hybrid sheet for stacking 3D cell culture. Cellulose, 2019,26: 6755–6768.
https://link.springer.com/article/10.1007%2Fs10570-019-02545-3
(16) Gang Xiao, Jing He, Xiaodie Chen, Yan Qiao, Feng Wang, Qingyou Xia, Ling Yu* & Zhisong Lu*. A wearable, cotton thread/paper-based microfluidic device coupled with smartphone for sweat glucose sensing. Cellulose. 2019, 26: 4553-4562.
https://link.springer.com/article/10.1007/s10570-019-02396-y
(15) Guorong Hou, Yanjing Yun, Minqiang Wang, Ying Wang, Hao Chen, Longcheng Zhang, Feng Wang, Qingyou Xia, Yang Liu, Zhisong Lu* & Shu-Juan Bao*. A coaxial nanocable textured by a cerium oxide shell and carbon core for sensing nitric oxide. Microchimica Acta, 2019, 186:789.
https://link.springer.com/article/10.1007/s00604-019-3839-1
(14) Wenjing Chen, Feng Wang, Chi Tian, Yuancheng Wang, Sheng Xu, Riyuan Wang, Kai Hou, Ping Zhao, Ling Yu, Zhisong Lu, and Qingyou Xia*. Transgenic Silkworm-Based Silk Gland Bioreactor for Large Scale Production of Bioactive Human Platelet-Derived Growth Factor (PDGF-BB) in Silk Cocoons. Int. J. Mol. Sci. 2018, 19(9), 2533.
https://doi.org/10.3390/ijms19092533
(13) Huihui Zhang, Zhuanzhuan Shi, Mengyao Zhou, Feng Wang, Qingyou Xia, Yan Qiao, Ling Yu and Zhisong Lu*. Cohesive thermoplastic-assisted patterning and assembly of a textile-supported piezoresistive sensor for monitoring human vital signs. Smart Mater. Struct. 2018. 27: 105027.
http://iopscience.iop.org/article/10.1088/1361-665X/aadb63/meta
(12) Zicong Zhao, Bintian Li, Liqun Xu, Yan Qiao, Feng Wang, Qingyou Xia and Zhisong Lu*. A Sandwich-Structured Piezoresistive Sensor with Electrospun Nanofiber Mats as Supporting, Sensing, and Packaging Layers. Polymers 2018, 10(6), 575.
https://doi.org/10.3390/polym10060575
(11) Jianping Duan, Xianxin Meng, Sanyuan Ma, Feng Wang, Huozhen Guo, Liying Zhang, Ping Zhao, Yunchao Kan, Lunguang Yao, Qingyou Xia*. The C-terminus of DSXF5 protein acts as a novel regulatory domain in Bombyx mori. Transgenic Res. 2016 Mar 15.
http://link.springer.com/article/10.1007/s11248-016-9946-4
(10) Hanfu Xu, Lin Yuan, Feng Wang, Yuancheng Wang, Riyuan Wang, Chunnuan Song, Qingyou Xia, Ping Zhao. Overexpression of recombinant infectious bursal disease virus (IBDV) capsid protein VP2 in the middle silk gland of transgenic silkworm. Transgenic Res. 2014, 23(5): 809-816.
http://link.springer.com/article/10.1007/s11248-014-9827-7
(9) Hanfu Xu, Yaowen Liu, Feng Wang, Lin Yuan, Yuancheng Wang, Sanyuan Ma, Helen Beneš, QingYou Xia*. Overexpression and functional characterization of an Aspergillus niger phytase in the fat body of transgenic silkworm, Bombyx mori. Transgenic Res. 2014, 23(4): 669-677.
http://link.springer.com/article/10.1007/s11248-014-9797-9
(8) Jianping Duan, Hanfu Xu, Shangyuan Ma, Huizheng Guo, Feng Wang, Liying Zhang, Xingfu Zha, Ping Zhao and Qingyou Xia*. Ectopic expression of the male BmDSX affects formation of the chitin plate in female Bombyx mori. Mol Reprod Dev. 2014 Mar; 81(3): 240-7.
http://onlinelibrary.wiley.com/doi/10.1002/mrd.22290/full
(7) Hanfu Xu, Dangjun Deng, Lin Yuan, Yuancheng Wang, Feng Wang, Qingyou Xia*. Identification of a functional element in the promoter of the silkworm (Bombyx mori) fat body-specific gene Bmlp3. Gene, 2014, 546(1): 129-134.
http://www.sciencedirect.com/science/article/pii/S0378111914006015
(6) Jianping Duan, Hanfu Xu, Huizhen Guo, David A. O'Brochta, Feng Wang, Sanyuan Ma, Liying Zhang, Xingfu Zha, Ping Zhao, Qingyou Xia*. New insights into the genomic organization and splicing of the doublesex gene, a terminal regulator of sexual differentiation in the silkworm Bombyx mori. PLoS One. 2013 Nov 7; 8(11): e79703. Doi: 10.1371/journal.pone.0079703.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079703
(5) DangJun Deng, HanFu Xu, Feng Wang, Xiaoli Duan, SanYuan Ma, ZhongHuai Xiang & QingYou Xia. The promoter of Bmlp3 gene can direct fat body-specific expression in the transgenic silkworm, Bombyx mori. Transgenic Res. 2013 Oct; 22(5): 1055-63.
http://link.springer.com/article/10.1007/s11248-013-9705-8
(4) Sanyuan Ma, Xiaogang Wang, Jitao Fei, Yuanyuan Liu, Jianping Duan, Feng Wang, Hanfu Xu, Ping Zhao, Qingyou Xia*. Genetic marking of sex using a W chromosome-linked transgene. Insect Biochem Mol Biol. 2013 Dec; 43(12):1079-86.
http://www.sciencedirect.com/science/article/pii/S0965174813001562
(3) Jianping Duan, Hanfu Xu, Sanyuan Ma, Huizhen Guo, Feng Wang, Ping Zhao, Qingyou Xia*. Cre-mediated targeted gene activation in the middle silk glands of transgenic silkworms. Transgenic Res. 2013 Jun; 22(3): 607-19.
http://link.springer.com/article/10.1007/s11248-012-9677-0
(2) Jianping Duan, Hanfu Xu, Feng Wang, Sanyuan Ma, Xingfu Zha, Huizhen Guo, Ping Zhao, Qingyou Xia*. Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori. Biochemical and Biophysical Research Communications. 431 (2013) 630–635.
http://www.sciencedirect.com/science/article/pii/S0006291X12024102
(1) Sanyuan Ma, Shengling Zhang, Feng Wang, Yong Liu, Yuanyuan Liu, Hanfu Xu, Chun Liu, Ying Lin, Ping Zhao, Qingyou Xia*. Highly efficient and precise genome editing in silkworm using custom TALENs. PLoS One. September 18, 2012. 7(9): e45035. (High citation article)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045035
Research details
https://www.researchgate.net/profile/Feng-Wang-266/research
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联系地址:重庆市北碚区西南大学（南区）蚕学宫，400715
Email: atp_bomb@163.com或wangf1986@swu.edu.cn