王叶菁
博士、副教授、硕士研究生导师
学习工作经历：
2000-2004，兰州大学，理学学士
2004-2009，兰州大学/清华大学联合培养，理学博士
2006-2009，浙江清华长三角研究院，科研助理
2009-2012，美国西南医学中心，科研助理
2012-2020，西南大学生物技术学院，副教授，硕士生导师
2020-至今，西南大学前沿交叉学科研究院生物学研究中心，副教授，硕士生导师
主要研究领域：
1. 家蚕功能基因研究、蚕丝蛋白的合成与调控研究；
2. 基于转基因和基因编辑技术的家蚕种质创制；
3. 蚕丝等天然高分子新材料的开发与利用；
成果情况：
主持国家自然科学基金青年基金、重庆市自然科学基金、重庆市教委科学技术研究重点项目、重庆市教委雏鹰计划研究项目、中央高校基本科研业务费等多项课题。主研国家自然科学基金面上项目、重庆市自然科学基金重点项目、重庆市百人计划启动基金、生物大分子国家重点实验室开放基金、中央高校科研业务费创新团队项目等多项课题。在Carbohydrate Polymers、Materials Science and Engineering C、International Journal of Biological Macromolecules等国际国内学术刊物发表论文40余篇。获得国家授权专利7项。担任国家自然科学基金、教育部学位中心、教育部学位与研究生教育发展中心、重庆市自然科学基金、四川省自然科学基金等评审专家。
指导学生情况：
指导研究生获得国家奖学金、重庆市三好学生、重庆市普通高校优秀毕业研究生、重庆市优秀学位论文、侯光炯奖学金、西南大学优秀毕业研究生、西南大学优秀硕士学位论文、西南大学三好研究生、校级优秀科技成果奖、西南大学优秀大学毕业生等多项荣誉称号；
指导研究生主持重庆市研究生科研创新项目、中央高校基本业务费等学生项目；指导研究生在第二届“东方紫杯”全国大学生蚕桑生物技术创新大赛中荣获硕士组一等奖；指导研究生获得家蚕基因组生物学国家重点实验室研究生“科研之星”一等奖；指导研究生获得西南大学生命科学学部优秀硕士学位论文一等奖。
指导高中生学员获重庆市青少年创新大赛二等奖，获重庆市雏鹰计划优秀指导教师称号。
代表性论文：
1.Cai, R., Tao G., Zhao, P., Xia, Q.Y., He, H.W.*, Wang, Y.J.*. POU-M2 promotes juvenile hormone biosynthesis by directly activating the transcription of juvenile hormone synthetic enzyme genes in Bombyx mori. Open biology, 2022,12(4): 220031.
2.Chen, H.Q.; Yang, W.; Zuo, H*.; He, H.W.; Wang, Y.J.*. Recent Advances of DNA Hydrogels in Biomedical Applications. Journal of Analysis and Testing, 2021, 5(2): 155-164, 特刊: SI.
3.Li, W.T.; Huang, Z.X.; Cai, R.; Yang, W.; He, H.W; Wang, Y.J.*. Rational Design of Ag/ZnO Hybrid Nanoparticles on Sericin/Agarose Composite Film for Enhanced Antimicrobial Applications. Int. J. Mol. Sci, 2021, 22(1), 105.
4.Huang,Z.X.; Wang,Y.J.; Wu,M.; Li,W.T.; Zuo,H.; Xiao,B.; Zhang,X.Q.; Wu,J.; He,H.W.*; Xia,Q.Y.. Sericin-based gadolinium nanoparticles as synergistically enhancing contrast agents for pH-responsive and tumor targeting magnetic resonance imaging. Materials and Design, 2021, 203:109600.
5.Tao, G.; Cai, R.; Wang, Y.J.*; Zuo, H.; He, H.W.*. Fabrication of antibacterial sericin based hydrogel as an injectable and mouldable wound dressing. Materials Science and Engineering: C, 2021, 119, 1111597.
6.Hou,H; He, H.W.; Wang, Y.J.*. Effects of SDS on the activity and conformation of protein tyrosine phosphatase from thermus thermophilus HB27.Scientific reports. 2020,10(1): 3195.
7.Wang, P.; He, H.W.; Cai, R.; Tao, G.; Yang, M.R.; Zuo, H.; Umar, A.; Wang, Y.J.* Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application. Carbohydrate Polymers. 2019, 212: 403-411.
8.Ai, L.S.; He, H.W.*; Wang, P.; Cai, R.; Tao, G.; Yang, M.R.; Liu, L.Y.; Zuo, H.; Zhao P.; Wang, Y.J.*. Rational design and fabrication of ZnONPs functionalized sericin/PVA antimicrobial sponge. Int J Mol Sciences. 2019, 20 (19):4796.
9.Tao, G.; Cai, R.; Wang, Y.J.; Liu, L.Y.; Zuo, H.; Zhao P.; Ahmad Umar, Mao,C.B.; Xia Q.Y.; He, H.W. Bioinspired design of AgNPs embedded silk sericin-based sponges for efficiently combating bacteria and promoting wound healing. Materials and Design. 2019, 180: 107940.
10.Song, K.; Li, Y.; He, H.W.; Liu, L.N.; Zhao P.; Xia Q.Y.; Wang, Y.J.*. A Novel Adenosine Kinase from Bombyx mori: Enzymatic Activity, Structure, and Biological Function. International Journal of Molecular Sciences. 2019, 20(15):3732-3745.
11.Tao, G. ; Wang, Y.J. ; Cai R.; Chang H.P.; Song K.; Zuo H.; Zhao P.; Xia Q.Y.; He H.W. Design and performance of sericin/poly (vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application. Materials Science & Engineering C. 2019, 101: 341-351.
12.Wang, Y.J.; Cai, R.; Tao, G.; Wang, P.; Zuo, H.; Zhao, P.; Umar, A.; He, H.W. A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability. Molecules. 2018, 23(7): 1821-1835.
13.Li, Y. ; Wang, Y.J.; Song, K.; Liu, L.N.; Cai, R.; Tao, G.; Zhao, P.; Zhou, H.M.; He, H.W. A rapid and sensitive colorimetric assay for the determination of adenosine kinase activity. Biochemical and biophysical research communications. 2018, 502(2): 250-254.
14.Yang, M.R.; Wang, Y.J.; Tao, G.; Cai, R.; Wang, P.; Liu, L.Y.; Ai, L.S.; Zuo, H.; Zhao, P.; Umar, A.; Mao, C.B.; He, H.W. Fabrication of Sericin/Agrose Gel Loaded Lysozyme and Its Potential in Wound Dressing Application. Nanomaterials. 2018, 8(4): 235-249.
15.Liu, L.Y., Cai, R.; Wang, Y.J.; Tao, G.; Ai, L.S.; Wang, P.; Yang, M.R.; Zuo, H.; Zhao, P.; He, H.W. Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application. International journal of molecular sciences. 2018, 19(10): 2875-2891.
16.Cai, R.; Tao, G.; He, H.W.; Guo, P.C.; Yang, M.R., Ding, C.X.; Zuo, H.; Wang, L.Y.; Zhao, P; Wang, Y.J*. In Situ Synthesis of Silver Nanoparticles on the Polyelectrolyte-Coated Sericin/ PVA Film for Enhanced Antibacterial Application. Materials. 2017, 10(8): 967-981.
17.He, H.W.; Tao, G.; Wang, Y.J.; Cai, R.; Guo, P.C.; Chen, L.Q.; Zuo, H.; Zhao, P.; Xia, Q.Y. In situ green synthesis and characterization of sericin-silver nanoparticle composite with effective antibacterial activity and good biocompatibility. Materials Science and Engineering C. 2017, 80: 509-516.
18.Cai, R.; Tao, G.; He, H.W.; Song, K.; Zuo, H.; Jiang W.C.; Wang, Y.J.* One-Step Synthesis of Silver Nanoparticles on Polydopamine-Coated Sericin/ Polyvinyl Alcohol Composite Films for Potential Antimicrobial Applications. Molecules. 2017, 22(5): 721-734.
19.He, H.W., Cai, R.; Wang, Y.J.; Tao, G.; Guo, P.C.; Zuo, H.; Chen, L.Q.; Liu, X.Y.; Zhao, P.; Xia, Q.Y. Preparation and characterization of silk sericin/PVA blend film with silver nanoparticles for wound healing application. International Journal of Biomacro- molecules. 2017, 104(Pt A): 457-464.
20.Liu, L.N.; Li, Y.; Wang, Y.J.; Zhao, P.; Wei, S.G.; Li, Z.Z.; Chang, H.P.; He, H.W. Biochemical characterization and functional analysis of the POU transcription factor POU-M2 of Bombyx mori. International Journal of Biological Macromolecules. 2016, 86: 701-708.
21.Liu, L.N.; Wang, Y.J.; Li, Y.; Lin, Y.; Hou, Y.; Zhang, Y.; Wei, S.G.; Zhao, P.; Zhao, P.; He, H.W. LBD1 of Vitellogenin Receptor Specifically Binds to the Female-Specific Storage Protein SP1 via LBR1 and LBR3. PLoS ONE. 2016, 11(9): e0162317.
22.Wang, Y.J.; He, H.W.; Liu, L.N.; Gao, C.Y.; Xu, S.; Zhao, P.; Xia, Q.Y. Inactivation and Unfolding of Protein Tyrosine Phosphatase from Thermus thermophilus HB27 during Urea and Guanidine Hydrochloride Denaturation. PLoS ONE. 2014, 9(9): e107932.
欢迎对本研究领域和研究方向感兴趣的同学加入本课题组!
联系方式：
Email：yjwang@swu.edu.cn