董照明
副研究员，硕士生导师
重庆英才“青年拔尖人才”
学习工作经历
2020~至今 西南大学生物学研究中心，副研究员，硕士生导师
2016~2020 西南大学家蚕基因组生物学国家重点实验室，副研究员，硕士生导师
2014~2016 西南大学家蚕基因组生物学国家重点实验室，博士后
2012~2014 西南大学-澳大利亚联邦科工组织，联合培养博士
2008~2014 西南大学家蚕基因组生物学国家重点实验室，博士（硕博连读）
2004~2008 西南大学生物技术学院，学士
获奖及荣誉
2022 西南大学本科优秀论文（一等奖）指导教师
2022 西南大学西塔学院优秀班主任
2021 重庆英才•青年拔尖人才
2019 重庆市科学技术奖-自然科学奖
2016 重庆市科协首届自然科学优秀学术论文
2015 重庆市优秀博士学位论文
学术兼职
2020至今 中国昆虫学会蛾类专业委员会委员
2020至今 重庆劳动教育科学研究会会员
担任Frontiers in Microbiology、Frontiers in Pharmacology、Frontiers Veterinary Science、Scientific Reports、Insects、Biomimetics等杂志审稿人
研究领域
1. 蚕丝蛋白的组成与功能。利用蛋白质组学等方法发掘组成蚕丝的新成分；结合生物化学、材料学等多学科交叉的方法研究蚕丝蛋白的理化特性、胶粘性、抗菌性等，揭示蚕丝蛋白特性与功能的分子机制。
2. 昆虫丝蛋白的起源与进化。建立泌丝昆虫及昆虫丝蛋白数据库，阐明丝蛋白序列结构特征与丝纤维材料理化特性的关系模型；回答丝蛋白起源与进化等基本科学问题；为改造和设计新型丝蛋白材料提供理论支撑。
3. 高性能生物材料的合成与应用。在解析昆虫丝蛋白优越性能机制的基础上，组合高强度、高弹性、强粘性、强抗菌性等特殊性能的分子模块，利用家蚕丝腺生物反应器合成并制备新型生物材料。
承担项目
主持国家自然科学基金面上项目“黄刺蛾茧的形成机制研究”，起止时间：2023.01-2026.12，排名1/共6人。
主持重庆英才计划项目（青年拔尖人才类别）“昆虫丝蛋白的系统解析及应用”，起止时间：2022.05-2024.05，排名1/共1人。
主持国家自然科学基金青年科学基金项目“蚕丝中Seroin蛋白的抗菌机制研究”，起止时间：2018.01-2020.12，排名1/共5人。
主持重庆市自然科学基金面上项目“丝胶蛋白黏附特性的形成机制及对蚕丝性能的影响机制研究”，起止时间：2019.07-2022.06，排名1/共5人。
发明专利
董照明，赵萍，张艳，雷雨田，夏庆友；一种家蚕卵胶蛋白的截短蛋白及其应用；国家发明专利，专利授权号：ZL202110158004.2
董照明，赵萍，夏庆友，诸鸿韬；Seroin蛋白的截短体及其应用；国家发明专利，专利授权号：ZL202011280285.0
赵萍，董照明，郭晓朦，张艳，夏庆友；家蚕蚕茧抗真菌蛋白酶抑制剂在抗真菌中的应用及其制备方法；国家发明专利，专利授权号：ZL201510698590.4
赵萍; 张晓璐; 董照明; 郭凯雨; 夏庆友；敲低Seroin1基因的家蚕双元转基因系统及家蚕纯裸蛹品种的制备方法；国家发明专利，专利授权号：ZL202010941104.8
赵萍，赵东超，张艳，董照明，夏庆友; 一种基于家蚕组织样品进行大规模蛋白质组学鉴定的方法; 国家发明专利，专利授权号：ZL201810479866.3
赵萍，张晓璐，郭凯雨，董照明，夏庆友；家蚕BmSPI51突变蛋白BmSPI51M及其制备方法和应用；国家发明专利，专利授权号：ZL202110174143.4
代表性论文（近5年）：
2023
Zhaoming Dong, Qingyou Xia, Ping Zhao. Antimicrobial components in the cocoon silk of silkworm, Bombyx mori. International Journal of Biological Macromolecules, 2023. 224: 68-78.
Xiaolu Zhang, Zhaoming Dong, Kaiyu Guo, Wenchao Jiang, Xianxian Wu, Jingmin Duan, Xinyuan Jing, Qingyou Xia, Ping Zhao. Identification and functional study of fhx-L1, a major silk component in Bombyx mori. International Journal of Biological Macromolecules. 2023, 232: 123371.
2022
Lixia Qin, Jing Li, Kaiyu Guo, Mengyao Lu, Yan Zhang, Xiaolu Zhang, Yanqiong Zeng, Xin Wang, Qingyou Xia, Ping Zhao, Ai-bing Zhang, Zhaoming Dong*. Insights into the structure and composition of mineralized hard cocoons constructed by the oriental moth, Monema (Cnidocampa) flavescens Walker. Insect Biochemistry and Molecular Biology, 2022, 151: 103878.
Kaiyu Guo, Xiaolu Zhang, Dongchao Zhao, Lixia Qin, Wenchao Jiang, Wenbo Hu, Xiao Liu, Qingyou Xia, Zhaoming Dong*, Ping Zhao*. Identification and characterization of sericin5 reveals non-cocoon silk sericin components with high beta-sheet content and adhesive strength. Acta Biomaterialia, 2022. 150: 96-110.
Dong Cheng, Zhaoming Dong, Ping Lin, Guanwang Shen, Qingyou Xia. Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers. International Journal of Molecular Sciences, 2022, 23(18): 10791.
Xin Wang, Xiaoqian Xie, Kang Xie, Qingsong Liu, Yi Li, Xiaoyin Tan, Haonan Dong, Xinning Li, Zhaoming Dong, Qingyou Xia, Ping Zhao. Chitin and cuticle proteins form the cuticular layer in the spinning duct of silkworm. Acta Biomaterialia, 2022, 145: 260-271.
Yueting Sun, Wenyu Shi, Quan Zhang, Haiqiong Guo, Zhaoming Dong, Ping Zhao, Qingyou Xia. Multi-Omics Integration to Reveal the Mechanism of Sericin Inhibiting LPS-Induced Inflammation. International Journal of Molecular Sciences, 2022, 24(1): 259.
2021
Yutian Lei, Kaiyu Guo, Yan Zhang, Xiaolu Zhang, Lixia Qin, Xin Wang, Hongtao Zhu, Yuanyuan Guo, Wenxin Yang, Benchi Li, Qingyou Xia, Ping Zhao, Zhaoming Dong*. Adhesive Property and Mechanism of Silkworm Egg Glue Protein. Acta Biomaterialia, 2021. 134: 499-512.
Zhaoming Dong, Lingna An, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen, Xiaolu Zhang, Yan Zhang, Qingyou Xia, Ping Zhao*. SPINK7 recognizes fungi and initiates hemocyte-mediated immune defence against fungal infections. Frontiers in Immunology, 2021. 12: 735497.
Zhaoming Dong, Lin Ye, Yan Zhang, Zhiyong Chen, Benchi Li, Tao Zhang, and Ping Zhao. Identification of N-linked Glycoproteins in Silkworm Serum Using Con A Lectin Affinity Chromatography and Mass Spectrometry. Journal of Insect Science, 2021. 21(4): 14.
Honglei Li#, Lin Wu#, Zhaoming Dong#, Yusong Jiang, Sanjie Jiang, Haitao Xing, Qiang Li, Guocheng Liu, Shuming Tian, Zhangyan Wu, Bin Wu, Zhexin Li, Ping Zhao, Yan Zhang, Jianmin Tang, Jiabao Xu, Ke Huang, Xia Liu, Wenlin Zhang, Qinhong Liao, Yun Ren, Xinzheng Huang, Qingzhi Li, Chengyong Li, Yi Wang, Baskaran Xavier-Ravi, Honghai Li, Yang Liu, Tao Wan, Qinhu Liu, Yong Zou, Jianbo Jian, Qingyou Xia and Yiqing Liu. Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway. Horticulture Research, 2021,8:189.
Lin Ye, Yan Zhang, Zhaoming Dong, Pengchao Guo, Dongchao Zhao, Haoyun Li, Hang Hu, Xiaofang Zhou, Haiqin Chen, Ping Zhao. Five Silkworm 30K Proteins Are Involved in the Cellular Immunity against Fungi. Insects, 2021. 12(2).107.
Xiaolu Zhang, Yuhui Ni, Kaiyu Guo, Zhaoming Dong, Yuqing Chen, Hongtao Zhu, Qingyou Xia, Ping Zhao. The mutation of SPI51, a protease inhibitor of silkworm, resulted in the change of antifungal activity during domestication. International Journal of Biological Macromolecules. 2021. 178: 63-70.
Xin Wang, Xiaoyin Tan, Qingsong Liu, Yi Li, Xinning Li, Zhaoming Dong, Haonan Dong, Qingyou Xia, and Ping Zhao. Fiber Formation and Mechanical Properties of Bombyx mori Silk Are Regulated by Vacuolar-Type ATPase. ACS Biomaterials Science & Engineering, 2021, 7(12): 5532-5540.
2020
Hongtao Zhu, Xiaolu Zhang, Mengyao Lu, Haiqin Chen, Shiyi Chen, Jiaxuan Han, Yan Zhang, Ping Zhao, Zhaoming Dong*. Antibacterial Mechanism of Silkworm Seroins. Polymers, 2020, 12(12): 2985.
Yan Zhang, Muya Tang, Zhaoming Dong, Dongchao Zhao, Lingna An, Hongtao Zhu, Qingyou Xia, Ping Zhao. Synthesis, secretion, and antifungal mechanism of a phosphatidylethanolamine-binding protein from the silk gland of the silkworm Bombyx mori. International Journal of Biological Macromolecules, 2020, 149, 1000-1007.
Xiaolu Zhang, Kaiyu Guo, Zhaoming Dong, Zhiyong Chen, Hongtao Zhu, Yan Zhang, Qingyou Xia, Ping Zhao. Kunitz-type protease inhibitor BmSPI51 plays an antifungal role in the silkworm cocoon. Insect Biochemistry and Molecular Biology, 2019, 103258.
Kaiyu Guo, Xiaolu Zhang, Zhaoming Dong, Yuhui Ni, Yuqing Chen, Yan Zhang, Haoyun Li, Qingyou Xia, Ping Zhao. Ultrafine and High-Strength Silk Fibers Secreted by Bimolter Silkworms. Polymers, 2020, 12(11): 2537.
Daoyuan Qin, Genhong Wang, Zhaoming Dong, Qingyou Xia Ping Zhao. Comparative fecal metabolomes of silkworms being fed mulberry leaf and artificial diet. Insects, 2020, 11(12): 851.
2019
Zhaoming Dong, Kaiyu Guo, Xiaolu Zhang, Tong Zhang, Yan Zhang, Sanyuan Ma, Huaipu Chang, Muya Tang, Lingna An, Qingyou Xia, Ping Zhao. Identification of Bombyx mori sericin 4 protein as a newbiological adhesive. International Journal of Biological Macromolecules. 2019, 132: 1121–1130.
Muya Tang, Zhaoming Dong, Pengchao Guo, Yan Zhang, Xiaolu Zhang, Kaiyu Guo, Lingna An, Xinyang Liu, Ping Zhao. Functional analysis and characterization of antimicrobial phosphatidylethanolamine-binding protein BmPEBP in the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology. 2019, 110: 1-9.
Shiyi Chen, Zhaoming Dong, Xiu Ren, Dongchao Zhao, Yan Zhang, Muya Tang, Jiaxuan Han, Lin Ye, Ping Zhao. Proteomic Identification of Immune-Related Silkworm Proteins Involved in the Response to Bacterial Infection. Journal of Insect Science. 2019. 19(4).
Sirong He, Dan Shi, Zhigang Han, Zhaoming Dong, Yajun Xie, Fengmei Zhang, WenXin Zeng, Qiying Yi. Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision. Biomed Eng Online, 2019, 18(1), 97.
Chenchen Lu, Zhiqing Li, Li Chang, Zhaoming Dong, Pengchao Guo, Guanwang Shen, Qingyou Xia, Ping Zhao. Efficient delivery of dsRNA and DNA in cultured silkworm cells for gene function analysis using PAMAM dendrimers system. Insects, 2019, 11(1): 12.
Zhangchuan Peng, Xi Yang, Chun Liu, Zhaoming Dong, Feng Wang, Xin Wang, Wenbo Hu, Xia Zhang, Ping Zhao, Qingyou Xia. Structural and mechanical properties of silk from different instars of Bombyx mori. Biomacromolecules. 2019, 20(3):1203-1216.
张艳，董照明，赵东超，李浩云，王凌燕，林英，赵萍. 基于超快速液相-质谱技术对野蚕茧和家蚕茧化学成分进行比较. 生物工程学报, 2019. 35(8): 1546-1556.
联系方式
E-mail：dongzhaoming@swu.edu.cn