张艳

副教授、硕士生导师

学习工作经历：

2003.09~2007.07   西南大学，学士

2007.09~2012.12   西南大学，博士（硕博连读）

2013.03~2015.03   西南大学，博士后

2015.04~2018.06   西南大学，助理研究员

2018.12-2019.12  英国华威大学，访问学者

2018.07~至今    西南大学，副教授

研究领域与方向：

1.昆虫的细胞自噬。自噬是一种进化上保守的分解代谢过程，其依赖溶酶体途径对胞

质蛋白和细胞器进行降解。自噬与衰老、神经退行性疾病、癌症、自身免疫病和心血管等疾病密切相关。我们主要以家蚕、果蝇等为实验对象，研究自噬在其中的作用，建立相关疾病模型，期望通过昆虫自噬的研究为人类疾病提供参考和借鉴。

2.昆虫的营养与代谢。昆虫是地球上数量最多、最为成功的一类动物。作为昆虫

中进化程度最高的完全变态昆虫一生要经历卵、幼虫、蛹和成虫四个阶段。无论是在卵期、蛹期或蜕皮变态期，昆虫均暂时停止进食，不能从外部获得营养。因此，昆虫的营养积累至关重要。课题组研究昆虫变态期的营养蛋白积累、储存、利用以及调控机理，为深入理解昆虫的发育变态奠定基础。

成果情况：

从事昆虫的营养与细胞自噬研究，已在Cell reports、Autophagy、STAR Protocols、Insect Biochem Mol Biol等杂志发表SCI文章50余篇；主持国家自然基金青年基金项目、重庆市自然科学基金面上项目、中国博士后科学基金项目等；与英国华威大学保持紧密合作关系。

代表性论文：

1.Jianhua Xia#, Haiqin Chen#, Yuying Wang, Wenbo Hu, Kaiyu Guo, Qingqing Linghu, Pengchao Guo, Xin Wang, Qingyou Xia, Ioannis P. Nezis, Ping Zhao*, Zhaoming Dong*, and Yan Zhang*. Defective autophagy in a fibroin secretion-deficient silkworm mutant. Autophagy, 2025, 21(11):2443-2455.

2.Qingqing Linghu#, Haoyun Li#, Jiahui Wan, Xiaolu Zhang, Jingjing Huang, Zhiqing Li, Yuying Wang, Jianhua Xia, Zhaoming Dong, Ying Lin, Ping Zhao*, Yan Zhang*. PBX and Dfd cooperatively regulate stage-specific expression of 30K protein BmLP1 in Bombyx mori. Insect Mol Biol. 2025;1–9.

3.Yan Zhang*, Nezis IP*. Label-free quantitative proteomic analysis of adult Drosophila heads. STAR Protoc. 2022 Nov 11;3(4):101830.

4. Raksha Gohel, Ashrafur Rahman, Peter Lőrincz, Anikó Nagy, Gábor Csordás, Yan Zhang, Gábor Juhász, Ioannis P Nezis*. Selective autophagy and Golgi quality control in Drosophila. Autophagy. 2022 Oct;18(10):2508-2509.

5. Ashrafur Rahman, Peter Lőrincz, Raksha Gohel , Anikó Nagy, Gábor Csordás, Yan Zhang, Gábor Juhász, Ioannis P Nezis*. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Cell Rep. 2022 May 31;39(9):110903.

6. Lin Ye#, Yan Zhang#, Zhaoming Dong, Pengchao Guo, Dongchao Zhao, Haoyun Li, Hang Hu, Xiaofang Zhou, Haiqin Chen, Ping Zhao*. Five silkworm 30K proteins are involved in the cellular immunity against Fungi. Insects. 2021, 12, 107.

7. Yan Zhang#, Muya Tang#, Zhaoming Dong, Dongchao Zhao, Lingna An, Hongtao Zhu, Qingyou Xia, Ping Zhao*. Synthesis, secretion, and antifungal mechanism of a phosphatidylethanolamine-binding protein from the silk gland of the silkworm Bombyx mori. Int J Biol Macromol. 149 (2020) 1000–1007.

8. Yan Zhang, Dongchao Zhao, Zhu Meng, Zhaoming Dong, Ying Lin, Shiyi Chen, Qingyou Xia, Ping Zhao*. Wild silkworm cocoon contains more metabolites than domestic silkworm cocoon to improve its protection. J Insect Sci, (2017) 17(5): 105; 1–6.

9. Yan Zhang#, Ping Zhao#, Zhaoming Dong, Dandan Wang, Xiaomeng Guo, Pengchao Guo, Qianru Song, Weiwei Zhang, Qingyou Xia*. Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori. PLoS One. 2015, 10(4): e0123403.

10. Yan Zhang, Zhaoming Dong, Peiming Gu, Weiwei Zhang, Dandan Wang, Xiaomeng Guo, Ping Zhao*, Qingyou Xia. Proteomics analysis of adult testis from Bombyx mori. Proteomics. 2014(14): 2345–2349.

11. Yan Zhang, Zhaoming Dong, Dandan Wang, Yong Wu, Qianru Song, Peiming Gu, Ping Zhao*, Qingyou Xia. Proteomics of larval hemolymph in Bombyx mori reveals various nutrient-storage and immunity-related proteins. Amino Acids. 2014(46):1021-1031.

12. Yan Zhang, Ping Zhao, Hongli Liu, Zhaoming Dong, Qiang Yang, Dandan Wang, Qingyou Xia*. The synthesis, transportation and degradation of BmLP3 and BmLP7, two highly homologous Bombyx mori 30K proteins. Insect Biochem Molec. 2012(42): 827-834.

13. Yan Zhang, Zhaoming Dong, Shiping Liu, Qiang Yang, Ping Zhao, Qingyou Xia*. Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 family. Funct Integr Genomic. 2012(12): 705-715.

14. Hong-Lei Li, Lin Wu, Zhaoming Dong, Yusong Jiang, Sanjie Jiang, Haitao Xing, Qiang Li, Guocheng Liu, Shuming Tian, Zhangyan Wu, Bin Wu, Zhexin Li, Ping Zhao, Yan Zhang, Jianmin Tang, Jiabao Xu, Ke Huang, Xia Liu, Wenlin Zhang, Qinhong Liao, Yun Ren, Xinzheng Huang, Qingzhi Li, Chengyong Li, Yi Wang, Baskaran Xavier-Ravi, Honghai Li, Yang Liu, Tao Wan, Qinhu Liu, Yong Zou*, Jianbo Jian*, Qingyou Xia*, Yiqing Liu*. Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway. Hortic. Res. 8, 189.

15. Yutian Lei, Kaiyu Guo, Yan Zhang, Xiaolu Zhang , Lixia Qin , Xin Wang, Hongtao Zhu , Yuanyuan Guo, Wenxin Yang , Benchi Li , Qingyou Xia, Ping Zhao*, Zhaoming Dong*. Adhesive property and mechanism of silkworm egg glue protein. Acta Biomater. 2021, 134, 499–512.

16. Dandan Wang, Zhaoming Dong, Yan Zhang, Kaiyu Guo, Pengchao Guo, Ping Zhao*, Qingyou Xia. Proteomics provides insight into the interaction between mulberry and silkworm. J. Proteome Res. 2017, 16, 2472−2480.

17. Dandan Wang, Yan Zhang, Zhaoming Dong, Pengchao Guo, Sanyuan Ma, Kaiyu Guo, Qingyou Xia, Ping Zhao*. Serine protease P-IIc is responsible for the digestion of yolk proteins at the late stage of silkworm embryogenesis. Insect Biochem Mol Biol. 2016, 74:42-49.

18. Zhaoming Dong, Ping Zhao, Chen Wang, Yan Zhang, Jianping Chen, Xin Wang, Ying Lin, Qingyou Xia*. Comparative proteomics reveal diverse functions and dynamic changes of Bombyx Mori silk proteins spun different development stages. J. Proteome Res. 2013, 11 (12): 5213-5222.

联系方式：

Email：zhangy66@swu.edu.cn