副教授、硕士生导师

Associate Professor, Master's Supervisor

简历：

主要科研领域与方向 Research Interests：

      蚕丝纤维成纤机制的研究：利用多组学的手段鉴定家蚕丝腺中与蚕丝成纤维相关的因子，系统性研究成纤维因子在蚕丝性能决定中的作用，阐释蚕丝蛋白成纤维的分子机制。

      高性能新型蚕丝纤维的开发和利用：通过遗传操作手段改变家蚕成纤维因子，对蚕丝纤维的性能进行定向改良，创制新型高性能蚕丝纤维品种与素材。

      My research interests center on two interconnected areas: understanding the mechanisms of silk fiber formation in silkworms and developing high-performance silk fibers through genetic manipulation. My work combines advanced scientific methodologies with practical applications, bridging fundamental biology and material science innovation.

      1. Mechanism of silk fiber formation in silkworms using multi-omics approaches

      I am deeply engaged in exploring how silk fibers are formed within the silkworm’s silk gland, employing multi-omics approaches to achieve a comprehensive understanding of this process. By combining these approaches, I dissect the complex interplay of genetic, molecular, and biochemical factors that drive silk fiber formation. My research has led to a groundbreaking theory: the fiberization process within the silk gland is the key determinant of silk properties, such as strength and elasticity. This foundational work provides deep insights into the biological processes that can be manipulated to enhance silk properties.

      2. Development of high-performance silk fibers through genetic manipulation

      My second major research interest is the development of high-performance silk fibers with superior mechanical properties. I achieve this through genetic manipulation, employing techniques such as gene editing and transgenic expression. By targeting genes and proteins identified in his multi-omics studies, I engineer silkworms to produce silk with improved attributes, including greater strength, stiffness, and toughness. A standout achievement is the creation of "Fe-silk", a genetically modified silk fiber that demonstrates 1.5 times greater strength and over twice the stiffness and toughness than conventional silk.

科学成就：

蚕丝成纤维机制研究理论有创新：首次提出丝腺中纤维化过程决定蚕丝性能的理论，鉴定了关键的成纤维因子，并对其功能进行了深入研究，从分子层面解析了蚕丝蛋白纤维化的机理。

新型高性能纤维拓展应用有突破：通过对蚕丝成纤维因子的遗传改造，成功创制多款力学性能显著提升的新型蚕丝纤维，其中“Fe蚕丝“纤维强度较对照提升1.5倍，刚度和韧度提升2倍以上，生丝纤维强伸度指标远超国标水平，具有重大应用价值，正进行推广。

      基于获得的系列原创性、开拓性成果，在Acta Biomaterialia、Biomacromolecules、Insect Biochemistry and Molecular Biology等权威杂志发表研究论文30余篇；获国家发明专利授权4项；主持国家自然科学基金面上项目，国家自然科学基金青年基金项目等国家级和省部级科研项目，参加国家重点研发计划、973等重大课题的研究。获2017年重庆市优秀博士学位论文奖励。长期担任Acta Biomaterialia、Biomacromolecules、International Journal of Biological Macromolecules等SCI期刊的审稿人。

      Based on a series of original and pioneering achievements, I have published more than 30 research articles in leading journals such as Acta Biomaterialia, Biomacromolecules, and Insect Biochemistry and Molecular Biology. I hold four granted Chinese invention patents. I have served as Principal Investigator for national- and provincial/ministerial-level projects, including an NSFC General Program grant and an NSFC Young Scientists Fund grant, and have participated in major national programs such as the National Key R&D Program of China and the “973” Program. I received the 2017 Chongqing Outstanding Doctoral Dissertation Award. I also serve as a long-term peer reviewer for SCI journals including Acta Biomaterialia, Biomacromolecules, and the International Journal of Biological Macromolecules.

指导学生：

 1.讲授课程：

2.指导学生项目：

3.指导学生获奖：

主持科研项目：

1.国家自然科学基金面上项目，家蚕前部丝腺特异表皮蛋白在角质层内膜构建及蚕丝纤维化中的功能研究，2023/1-2026/12

2.重庆市自然科学基金，超量表达表皮蛋白改良蚕丝纤维力学性能的研究，2024/7-2027/6

3.中央高校基本科研业务费，蚕丝性能决定因子在高性能蚕丝素材创制中的应用，2022/1-2024/12

4.国家自然科学基金青年基金项目，家蚕纺丝管道与蚕丝力学性能定向改良，2020/1-2022/12

5.西南大学博士启动基金项目，金属离子介导蚕丝力学性能定向改良的基础研究，2018/9-2020/12

6.中国博士后科学基金第60批面上项目一等资助，蚕丝纤维化机制研究及新型蚕丝纤维的开发，2016/7-2018/6

7.重庆市2017年博士后科研项目特别资助二等资助，利用金属离子对蚕丝纤维性能进行定向改良的基础研究，2017/7-2018/6

代表性论文/论著（仅列第一作者及通讯作者论文）：

Representative publications (limited to first-author and corresponding-author articles only):

1.Huang Q, Hu X, Fan X, Li YC, Wei M, Li X, Liu K, Lin Z, Li Y, Dong Z, Zhao P, Xia Q, Wang X*, Longer duct, better silk: unveiling how anterior silk gland length boosts fiber performance, Biomacromolecules, 2025, 26(7): 4262-4273. Link: https://pubs.acs.org/doi/10.1021/acs.biomac.5c00275

2.Fan X, Wei M, Li Y, Xia Q, Wang X*, Genetic engineering of silkworm for enhanced silk mechanical properties: a review, Materials & Design, 2025, 115031. Link: https://doi.org/10.1016/j.matdes.2025.115031

3.Su Z#, Li Y#, Lin Z, Huang Q, Fan X, Dong Z, Xia Q, Zhao P, Wang X*, GC–MS-based metabonomic analysis of silkworm haemolymph reveals four-stage metabolic responses to nucleopolyhedrovirus infection, Insect Mol Biol, 2025, 12972. Link: https://resjournals.onlinelibrary.wiley.com/doi/10.1111/imb.12972

4.Liu Q#, Wang X#, Zhou Y#, Li Y, Peng Z, Tang Z, Cai X, Fan X, Tang X, Tan X, Xie X, Li X, Dong Z, Zhao P*, Xia Q*, Fe-reinforced silkworm silk with superstrong mechanical properties for mass production, Chem Eng J, 2024, 496: 153613. Link: https://doi.org/10.1016/j.cej.2024.153613

5.黄晴, 苏振岳, 周一帆, 刘青松, 李懿, 赵萍, 王鑫*, 饲料与桑叶饲喂的家蚕蚕丝品质分析, 纺织学报, 2024, 45(05):1-9.

6.Wang X#, Xie X#, Xie K, Liu Q, Li Y, Tan X, Dong H, Li X, Dong Z, Xia Q, Zhao P*, Chitin and cuticle proteins form the cuticular layer in the spinning duct of silkworm, Acta Biomater, 2022, 145: 260-271. Link: https://doi.org/10.1016/j.actbio.2022.03.043

7.王鑫, 李懿, 刘青松, 李心宁, 夏庆友, 赵萍*, 硝酸钙盐缩处理对生丝结构与力学性能的影响, 西南大学学报（自然科学版）, 2022, 44(8): 77-84.

8.Wang X#, Tan X#, Liu Q, Li Y, Li X, Dong Z, Dong H, Xia Q, Zhao P*, Fiber formation and mechanical properties of Bombyx mori silk are regulated by vacuolar-type ATPase, ACS Biomater Sci Eng, 2021, 7(12): 5532–5540. Link: https://doi.org/10.1021/acsbiomaterials.1c01230

9.Wang X, Li Y, Liu Q, Tan X, Xie X, Xia Q, Zhao P*, GC/MS-based metabolomics analysis reveals active fatty acids biosynthesis in the Filippi's gland of the silkworm, Bombyx mori, during silk spinning, Insect Biochem Mol Biol, 2019, 105: 1-9. Link: https://doi.org/10.1016/j.ibmb.2018.12.009

10.Wang X, Li Y, Peng L, Chen H, Xia Q, Zhao P*, In vivo effects of metal ions on conformation and mechanical performance of silkworm silks, Biochim Biophys Acta, 2017, 1861(3): 567-576. Link: https://doi.org/10.1016/j.bbagen.2016.11.025

11.Wang X, Li Y, Liu Q, Xia Q, Zhao P*, Proteome profile of spinneret from the silkworm, Bombyx mori, Proteomics, 2017, 17(12): 1600301. Link: https://doi.org/10.1002/pmic.201600301

12.Wang X, Li Y, Peng L, Chen H, Xia Q, Zhao P*, Comparative transcriptome analysis of Bombyx mori spinnerets and Filippi's glands suggests their role in silk fiber formation, Insect Biochem Mol Biol, 2016, 68: 89-99. Link: https://doi.org/10.1016/j.ibmb.2015.11.003

13.Wang X#, Zhao P#, Li Y, Yi Q, Ma S, Xie K, Chen H, Xia Q*, Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation, Biomacromolecules, 2015, 16(10): 3119-3125. Link: https://doi.org/10.1021/acs.biomac.5b00724

14.Wang X, Li Y, Xie K, Yi Q, Chen Q, Wang X, Shen H, Xia Q, Zhao P*, Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties, J Insect Physiol, 2015, 73: 53-59. Link: https://doi.org/10.1016/j.jinsphys.2015.01.002

15.王鑫, 李懿, 陈慧芳, 周小英, 谢康, 赵萍*, 利用家蚕杆状病毒表达家蚕肌质网型钙离子ATP酶蛋白, 生物工程学报, 2015, 31(3): 421-430.

16.王鑫, 李懿, 陈全梅, 衣启营, 谢康, 吴用, 赵萍*, 家蚕空泡型ATP酶（V-ATPase）基因的基本信息及表达特征, 中国农业科学, 2014, 47(8): 1611-16

个人简介：

本人MBTI为ENFJ，性格开朗，为人随和。热爱科研的同时热爱生活，爱好唱歌、游泳，电影、旅游。欢迎志趣相投的同学加入课题组，一起在科研与生活中发现更多乐趣！

联系地址：重庆市北碚区西南大学蚕学宫411，400715

E-mail：swuwangxin@swu.edu.cn; xinwnag212@gmail.com