王元成
博士 副研究员
学习工作经历
2024.1至今，西南大学，副研究员
2021.2-2023.12，西南大学，预聘副教授
2018.7-2021.1, 西南大学, 博士后，合作导师: 夏庆友
2012.9–2018.6, 西南大学, 遗传学, 博士, 导师: 夏庆友
2008.9–2012.6, 西南大学, 蚕学, 学士, 导师: 徐立
研究领域
采用生物学、化学与材料学方法，开发蚕丝资源在再生医学、纺织及环境领域的新用途与新场景。主要研究方向包括：1）家蚕种质资源创新；2）医用蚕丝/蚕丝蛋白基生物材料的开发与应用；3）环境用蚕丝/蚕丝蛋白基材料的开发与应用。
成果情况
建立并优化了可在家蚕丝腺与蚕丝中高效特异性表达多个外源靶标蛋白的多基因表达系统，成功表达多种重组蛋白并创制出系列新型家蚕品系，包括表达人源成纤维细胞生长因子-1/2、转化生长因子-β1、结缔组织生长因子、猪源胰蛋白酶原及FAST-PETase等功能性蛋白的品系，获得具备促进细胞增殖与伤口愈合、蚕丝自脱胶、降解PET塑料等特性的新型蚕丝素材。以通讯作者或第一作者身份在《Journal of Hazardous Materials》《Journal of Advanced Research》《Acta Biomaterialia》《International Journal of Biological Macromolecules》《Biomaterials Science》等国际期刊发表SCI论文9篇，累计发表26篇；申请及授权国家发明专利9项；创制功能性蚕丝素材及家蚕新品系10余个；主持或主研多个国家级、省部级与校级科研项目。作为第4完成人获2024年度重庆市自然科学奖二等奖（项目名称：家蚕蚕丝抗菌机理及医用蚕丝材料创制）；成果“新型蚕丝可降解塑料家蚕品系”入选中国丝绸协会2024年度“丝绸领域十大科技成果”。
代表性论文/论著
1.Xinyu Tang, et al., Yuancheng Wang. Genetically engineered silk-based core-shell cytokine-ericin-carboxychitosan composite biomaterials for enhanced cell proliferation and medical applications[J]. Int J Biol Macromol, 2026, 339(Pt 1):149903.
2.Chi Tian#, Yuancheng Wang#, et al. Novel genetically engineered silk materials for recycling polyethylene terephthalate (PET) plastic waste[J].J Hazard Mater, 2025, 496:139446.
3.Riyuan Wang#, Yuancheng Wang#, et al. A novel method for silkworm cocoons self-degumming and its effect on silk fibers[J]. J Adv Res, 2023:53:87-98.
4.Yuancheng Wang, et al. Human-derived cytokine functionalized sericin/agarose composite gel material with cell proliferation-promoting activity fabricated using genetically engineered silk for medical application[J]. Materials & Design, 2022, 224:111362.
5.Yuancheng Wang, et al. Transdermal peptide conjugated to human connective tissue growth factor with enhanced cell proliferation and hyaluronic acid synthesis activities produced by a silkworm silk gland bioreactor[J]. Appl Microbiol Biotechnol, 2020, 104(23):9979-9990.
6.Yuancheng Wang, et al. Genetic fabrication of functional silk mats with improved cell proliferation activity for medical applications[J]. Biomater Sci, 2019, 7(11):4536-4546.
7.Yuancheng Wang, et al. Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm[J].Mol Genet Genomics, 2019, 294(4):849-859.
8.Yuancheng Wang, et al. Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application[J]. Acta Biomaterialia,2019(86) :148-157. doi: 10.1016/j.actbio.2018.12.036.
9.Yuancheng Wang, et al. 2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori[J] Sci Rep. 2015, 5:16273. doi: 10.1038/srep16273.
联系方式
Email：wangyc123@swu.edu.cn