张晓璐
副教授，硕士生导师
学习工作经历
2023.4 - 至今 西南大学 副教授
2021.1-2023.3 西南大学 生物学，博士后
2014.9-2020.12 西南大学 农学博士
2010.9-2014.6 山东农业大学 农学学士
研究领域
1. 家蚕蚕丝蛋白的组学鉴定及家蚕成丝机理的研究。利用多组学手段发掘蚕丝中的高丰度蛋白，系统性研究蚕丝蛋白的功能，揭示蚕丝蛋白影响家蚕吐丝的机理，阐明家蚕泌丝机制。
2. 基于丝蛋白基因编辑的种质创制和蚕丝素材创制。通过遗传操作手段改变家蚕丝纤维蛋白成分，创制新型蚕丝纤维素材。
获奖及荣誉
2021 重庆市优秀博士学位论文
成果情况：
发明专利：
1.赵萍; 张晓璐; 董照明;郭凯雨;夏庆友; 敲低Seroin1基因的家蚕双元转基因系统及家蚕纯裸蛹品种的制备方法，中国，2020109411048；
2. 赵萍; 张晓璐; 郭凯雨; 董照明; 夏庆友; 家蚕BmSPI51突变蛋白BmSPI51M及其制备方法和应用, 中国, 2021101741434。
承担项目：
1、国家自然科学基金青年项目：Seroin1通过影响丝胶层蛋白合成参与家蚕成纤过程的机制研究，起止时间：202301-202512，主持；
2、中国博士后面上资助项目：丝蛋白Seroin1在家蚕丝素蛋白构象转变过程中的作用机制研究，起止时间：202110-202304，主持；
3、重庆市博士后面上资助项目：Seroin1蛋白在家蚕丝蛋白构象转变过程中的作用机制研究及新素材创制，202110-202309，主持；
4、重庆市博士后特别资助项目：通过基因编辑实现家蚕多元化新型丝胶材料的制备，起止时间：202205-202304，主持；
5、国家自然科学基金面上项目：家蚕新丝胶蛋白的鉴定与功能研究，起止时间：202201-202512，参与。
代表性论文
1.Xiaolu Zhang, Zhaoming Dong, Kaiyu Guo, Wenchao Jiang, Xianxian Wu, Jingmin Duan, Xinyuan Jing, Qingyou Xia, Ping Zhao. Identification and functional study of fhx-L1, a major silk component in Bombyx mori [J]. International Journal of Biological Macromolecules, 2023, 232:123371.
2. Xiaolu Zhang#, Yuhui Ni#, Kaiyu Guo, Zhaoming Dong, Yuqing Chen, Hongtao Zhu, Qingyou Xia, Ping Zhao. Comparing the antifungal activity of BmSPI51 and WildSPI51 reveals the key role of the active site and C-terminal tail [J]. International Journal of Biological Macromolecules,2021,178：63-70.
3. Xiaolu Zhang#, Kaiyu Guo#, Zhaoming Dong, Zhiyong Chen, Hongtao Zhu, Yan Zhang, Qingyou Xia, Ping Zhao. Kunitz-type protease inhibitor BmSPI51 plays an antifungal role in the silkworm cocoon[J]. Insect Biochem Mol Biol, 2020, 116: 103258.
4. Xiaolu Zhang, Huaipu Chang, Zhaoming Dong, Yan Zhang, Dongchao Zhao, Lin Ye, Qingyou Xia, and Ping Zhao. Comparative proteome analysis reveals that cuticular proteins analogous to peritrophin-motif Proteins are involved in the regeneration of chitin layer in the silk gland of Bombyx mori at the molting stage[J]. proteomics, 2018, 18 (19): e1700389.
5. Kaiyu Guo#, Xiaolu Zhang#, Dongchao Zhao, Lixia Qina, Wenchao Jiang, Wenbo Hua, Xiao Liu, Qingyou Xia, Zhaoming Dong, Zhaoming Dong, Ping Zhao. Identification and characterization of sericin5 reveals non-cocoon silk sericin components with high β-sheet content and adhesive strength [J]. Acta Biomater, 2022, 150:96-110.（Co-first author）
6. Hongtao Zhu#, Xiaolu Zhang#, Mengyao Lu, Haiqin Chen, Shiyi Chen, Jiaxuan Han, Yan Zhang, Ping Zhao, Zhaoming Dong. Antibacterial Mechanism of Silkworm Seroins. Polymers.2020,12: 2985-2997.（Co-first author）
7. Kaiyu Guo, Xiaolu Zhang, Zhaoming Dong, Yuhui Ni, Yuqing Chen, Yan Zhang, Haoyun Li, Qingyou Xia, Ping Zhao. Ultrafine and High-Strength Silk Fibers Secreted by Bimolter Silkworms[J]. Plymers, 2020, 12 (11): 1000-1007.
8. Kaiyu Guo, Zhaoming Dong, Xiaolu Zhang, Yuqing Chen, Yi Li, Wenchao Jiang, Lixia Qin, Yan Zhang, Zhouguanrui Guo, Qingyou Xia, Ping Zhao. Analysis of histomorphometric and proteome dynamics inside the silk gland lumen of Bombyx mori revealed the dynamic change of silk protein during the molt stage [J]. International Journal of Biological Macromolecules, 2023, 236:123926.
9. Lei Y, Guo K, Zhang Y, Zhang X, Qin L, Wang X, Zhu H, Guo Y, Yang W, Li B, Xia Q, Zhao P, Dong Z, Adhesive property and mechanism of silkworm egg glue protein, Acta biomaterialia, 2021,134: 499-512.
10. Zhaoming Dong, Kaiyu Guo, Xiaolu Zhang, Tong Zhang, Yan Zhang, Sanyuan Ma, Huaipu Chang, Muya Tang, Lingna An, Qingyou Xia, Ping Zhao. Identification of Bombyx mori sericin4 protein as a new biological adhesive[J]. International Journal of Biological Macromolecules, 2019, 132: 1121-1130.
11. Zhaoming Dong, Weiwei Zhang, Yan Zhang, Xiaolu Zhang, Ping Zhao, Qingyou Xia. Identification and characterization of novel chitin-binding proteins from the larval cuticle of silkworm, Bombyx mori[J]. Journal of Proteome Research, 2016, 15 (5): 1435-1445.
12. Muya Tang, Zhaoming Dong, Pengchao Guo, Yan Zhang, Xiaolu Zhang, Kaiyu Guo, Lingna An, Xinyang Liu, Ping Zhao. Functional analysis and characterization of antimicrobial phosphatidylethanolamine-binding protein BmPEBP in the silkworm Bombyx mori[J]. Insect Biochem Mol Biol, 2019, 110:1-9.
13. Zhaoming Dong, Ping Zhao, Yan Zhang, Qianru Song, Xiaolu Zhang, Pengchao Guo, Dandan Wang, Qingyou Xia. Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori[J]. Scientific Reports, 2016, 6: 21158-21168.
14. Zhaoming Dong, Qianru Song, Yan Zhang, Shiyi Chen, Xiaolu Zhang, Ping Zhao, Qingyou Xia. Structure, evolution, and expression of antimicrobial silk proteins, seroins in Lepidoptera[J]. Insect Biochem Mol Biol, 2016, 75: 24-31.
15. Zhaoming Dong, Xiaohuan Wang, Yan Zhang, Liping Zhang, Quanmei Chen, Xiaolu Zhang, Ping Zhao, Qing you Xia. Proteome profiling reveals tissue-specific protein expression in male and female accessory glands of the silkworm, Bombyx mori[J]. Amino Acids, 2016, 48(5): 1173-83.
16. Kaiyu Guo, Zhaoming Dong, Yan Zhang, Dandan Wang, Muya Tang, Xiaolu Zhang, Qingyou Xia, Ping Zhao. Improved strength of silk fibers in Bombyx mori trimolters induced by an anti-juvenile hormone compound[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018,1862 (5): 1148-1156.
17. Zhaoming Dong, Lingna An, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen, Xiaolu Zhang, Yan Zhang, Qingyou Xia, Ping Zhao. SPINK7 Recognizes Fungi and Initiates Hemocyte-Mediated Immune Defense Against Fungal Infections[J]. Frontiers in Immunology,2021,735497.
18. 张艳，董照明，席星航，张晓璐，叶林，郭凯雨，夏庆友，赵萍. 家蚕脱胶蚕丝的蛋白组成成分[J]. 中国农业科学, 2018,51 (11):2216-2224.
19. 张薇薇，董照明，张艳，张晓璐，张守亚，赵萍. 家蚕表皮蛋白BmCPAP3-G的表达特征及其与几丁质的结合特性[J]. 中国农业科学, 2017, 50 (9):1723-1733.
20. 刘华伟，李游山，唐新，张晓璐，赵萍. 家蚕丝氨酸蛋白酶BmSP141的表达特征及对饥饿的响应[J]. 中国农业科学, 2016,49 (6):1207-1218.
联系方式
Email：zhangxiaolu@swu.edu.cn