刘华伟

副研究员、硕士生导师

学习工作经历

2021.7--至今 西南大学，讲师、副研究员

2018.7-2021.6   西南大学，博士后

2012.9-2018.6   西南大学，硕博连读，理学博士

2008.9-2012.6   河南大学，本科，理学学士

研究领域

1. 昆虫蜕皮与变态的分子调控机制

系统鉴定昆虫蜕皮相关丝氨酸蛋白酶的组成、功能及调控网络，深化对昆虫蜕皮分子机制的理解，筛选可作为新型绿色杀虫剂设计靶标的功能基因。

2. 家蚕免疫与代谢调控机制

（1）研究家蚕先天免疫信号通路中关键调控分子的功能，鉴定下游效应基因及交叉互作通路，揭示其免疫稳态维持的分子基础；

（2）探究家蚕肠道免疫与代谢稳态、微生物群落之间的互作关系，解析家蚕肠道稳态的调控网络；

（3）基于家蚕先天免疫和肠道稳态调控机制，通过改良肠道微环境及饲料添加剂策略，培育具有高抗病性和优良人工饲料适应性的种质素材。

研究聚焦于昆虫发育与免疫调控机制，主要围绕昆虫蜕皮过程及家蚕免疫稳态的分子调控机制展开。相关研究成果以第一作者发表于PLoS Pathogens、Insect Science、FEBS Journal、Insect Molecular Biology等学术期刊。主持国家自然科学基金面上项目、青年科学基金项目及多项省部级科研项目。

代表性论文：

1）Liu HW#, Sun XT#, Li YT, Tang ZC, Hou Y, Xia QY, Zhao P*. Peptidoglycan recognition protein L1 regulates intestinal immunity and microbial homeostasis via the IMD pathway in the silkworm, Bombyx mori. Insect Sci. 2025 Oct 28. DOI: 10.1111/1744-7917.70178

2) Tang X#, Liu HW#, Chang L, Wang X, Liu QS, Tang ZC, Xia QY, Zhao P*. A strategy for improving silk yield and organ size in silk-producing insects, FEBS J, 2024, Oct;291(19):4286-4300. DOI: 10.1111/febs.17193

3) Liu HW#, Xu JH#, Wang LL, Guo PC, Tang ZC, Sun XT, Tang X, Wang W, Wang LY, Cao Y, Xia QY, Zhao P*. Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori, PLoS Pathog, 2023, 19(10): e1011740. DOI: 10.1371/journal.ppat.1011740

4）Liu HW, Heng JY, Wang LL, Li YS, Tang X, Huang X, Xia QY, Zhao P*. Homeodomain proteins POU-M2, antennapedia and abdominal-B are involved in regulation of the segment-specific expression of the clip-domain serine protease gene CLIP13 in the silkworm, Bombyx mori, Insect Sci, 2022, 29(1):111-127. DOI: 10.1111/1744-7917.12916

5) Heng JY#, Liu HW#, Xu JH, Huang X, Sun XT, Yang RZ, Xia QY, Zhao P*. KPI5 is involved in the regulation of the expression of antibacterial peptide genes and hemolymph melanization in the silkworm, Bombyx mori. Front. Immunol, 2022, 13:907427. DOI: 10.3389/fimmu.2022.907427

6）Liu HW, Heng JY, Wang LL, Tang X, Guo PC, Li YS, Xia QY, Zhao P*. Identification, characterization, and expression analysis of clip-domain serine protease genes in the silkworm, Bombyx mori. Dev Comp Immunol, 2020, 105:103584. DOI: 10.1016/j.dci.2019.103584

7) Liu HW, Wang LL, Tang X, Dong ZM, Guo PC, Zhao DC, Xia QY, Zhao P*. Proteomic analysis of Bombyx mori molting fluid: Insights into the molting process. J Proteomics, 2018, 173:115-125. DOI: 10.1016/j.jprot.2017.11.027

8) Liu HW, Wang LL, Meng Z, Tang X, Li YS, Xia QY, Zhao P*. A clip domain serine protease involved in moulting in the silkworm, Bombyx mori: cloning, characterization, expression patterns and functional analysis. Insect Mol. Biol, 2017, 26(5):507-521. DOI: 10.1111/imb.12312

9) Liu HW, Li YS, Tang X, Guo PC, Wang DD, Zhou CY, Xia QY, Zhao P*. A midgut-specific serine protease, BmSP36, is involved in dietary protein digestion in the silkworm, Bombyx mori. Insect Sci, 2017, 24(5):753-767. DOI: 10.1111/1744-7917.12369

10) 刘华伟，李游山，唐新，张晓璐，赵萍^*. 家蚕丝氨酸蛋白酶BmSP141的表达特征及对饥饿的响应。 中国农业科学，2016，49(6):1207-1218.

(注：#co-first authors)

联系方式：

微信号：liuhw096

E-mail：liuhw096@swu.edu.cn