张同

博士后

学习工作经历

2010-2014 山东农业大学 蚕学专业 农学学士

2014-2023 西南大学 生物化学与分子生物学专业 理学博士（硕博连读）

2023-至今 西南大学与西部(重庆)科学城种质创制大科学中心联培 博士后

研究领域

通过生物多组学大数据分析手段，探究鳞翅目物种基因组功能、个体发育和漫长而有趣的进化之旅。

主要研究方向：

① 通过三维基因组与泛基因组研究，解析个体发育与物种进化；

② 基于CRISPR/Cas9 全基因组编辑技术进行规模化遗传筛选。

成果情况

1. Zhang T, Xing W, Wang A, Zhang N, Jia L, Ma S, Xia Q. (2022). Comparison of Long-Read Methods for Sequencing and Assembly of Lepidopteran Pest Genomes. Int J Mol Sci. 2022 Dec 30;24(1):649.

2. Ma S, Zhang T, Wang R, Wang P, Liu Y, Chang J, Wang A, Lan X, Sun L, Sun H, Shi R, Lu W, Liu D, Zhang N, Hu W, Wang X, Xing W, Jia L, Xia Q. High-throughput and genome-scale targeted mutagenesis using CRISPR in a nonmodel multicellular organism, Bombyx mori. Genome Res. 2024 Feb 7;34(1):134-144.

3. Lu W, Zhang T, Zhang Q, Zhang N, Jia L, Ma S, Xia Q. FibH Gene Complete Sequences (FibHome) Revealed Silkworm Pedigree. Insects. 2023; 14(3):244.

4. Lu W, Ma S, Sun L, Zhang T, Wang X, Feng M, Wang A, Shi R, Jia L, Xia Q. Combined CRISPR toolkits reveal the domestication landscape and function of the ultra-long and highly repetitive silk genes. Acta Biomater. 2023 Jan 2:S1742-7061(22)00874-1.

5. Lu W, Lan X, Zhang T, Sun H, Ma S, Xia Q. Precise Characterization of Bombyx mori Fibroin Heavy Chain Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies. Insects. 2021 Sep 16;12(9):832.

6. Chang, J., Chen, X., Zhang, T., Wang, R., Wang, A., Lan, X., . . . Xia, Q. (2020). The novel insight into the outcomes of CRISPR/Cas9 editing intra- and inter-species. Int J Biol Macromol, 163, 711-717.

7. Chang, J., Wang, R., Yu, K., Zhang, T., Chen, X., Liu, Y., . . . Ma, S. (2020). Genome-wide CRISPR screening reveals genes essential for cell viability and resistance to abiotic and biotic stresses in Bombyx mori. Genome Res, 30(5), 757-767.

8. Dong, Z., Guo, K., Zhang, X., Zhang, T., Zhang, Y., Ma, S., . . . Zhao, P. (2019). Identification of Bombyx mori sericin 4 protein as a new biological adhesive. Int J Biol Macromol, 132, 1121-1130.

9. Jia, L., Ma, S. Y., Zhang, T., Xing, W. Q., Liu, Y., Li, Y. F., . . . Xia, Q. Y. (2019). Enhanced Bombyx genome editing via Cas9 ribonucleoprotein injection. Insect Sci, 26(6), 1059-1062.

10. Li, Y., Ma, S., Sun, L., Zhang, T., Chang, J., Lu, W., . . . Xia, Q. (2018). Programmable Single and Multiplex Base-Editing in Bombyx mori Using RNA-Guided Cytidine Deaminases. G3 (Bethesda), 8(5), 1701-1709.

11. Liu, Y., Chang, J., Yang, C., Zhang, T., Chen, X., Shi, R., . . . Ma, S. (2021). Genome-wide CRISPR-Cas9 screening in Bombyx mori reveals the toxicological mechanisms of environmental pollutants, fluoride and cadmium. J Hazard Mater, 410, 124666.

12. Liu, Y., Ma, S., Chang, J., Zhang, T., Chen, X., Liang, Y., & Xia, Q. (2019). Programmable targeted epigenetic editing using CRISPR system in Bombyx mori. Insect Biochem Mol Biol, 110, 105-111.

13. Liu, Y., Ma, S., Chang, J., Zhang, T., Wang, X., Shi, R., . . . Xia, Q. (2017). Tissue-specific genome editing of laminA/C in the posterior silk glands of Bombyx mori. J Genet Genomics, 44(9), 451-459.

14. Ma, S., Liu, Y., Liu, Y., Chang, J., Zhang, T., Wang, X., . . . Xia, Q. (2017). An integrated CRISPR Bombyx mori genome editing system with improved efficiency and expanded target sites. Insect Biochem Mol Biol, 83, 13-20.

15. Ma, S., Wang, A., Chen, X., Zhang, T., Xing, W., & Xia, Q. (2021). Deep Sequencing Reveals the Comprehensive CRISPR-Cas9 Editing Spectrum in Bombyx mori. Crispr j, 4(3), 371-380.

16. Shi, R., Ma, S., He, T., Peng, J., Zhang, T., Chen, X., . . . Zhao, P. (2019). Deep Insight into the Transcriptome of the Single Silk Gland of Bombyx mori. Int J Mol Sci, 20(10).

17. Sun H, Chen J, Wang R, Liu D, Zhang N, Zhang T, Jia L, Ma S, Xia Q. Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm (Bombyx mori). Insect Sci. 2024 Feb;31(1):47-58.

联系方式

邮箱：zt137703197@email.swu.edu.cn

电话：17623707442